Abstract
Serotonin signals in neurons are transduced by a large and rapidly growing family of receptors. To date, four principal types of serotonin receptor have been identified, designated 5-HT1-5-HT4. 5-HT1 receptors have high (nanomolar) affinity for serotonin. Three 5-HT1 subtypes have been identified by molecular cloning: 5-HT1a (Fargin et al. 1988; Albert et al. 1990), 5-HT1c (Julius et al. 1988), and 5HT1d. In addition, 5-HT1b and 5-HT1e receptors have been characterized pharmacologically, but their sequences have not yet been deduced from cloned cDNAs. The members of the 5-HT1 family are all G protein linked receptors; the 5-HT1a (DeVivo and Maayani 1985), 5-HT1b (Ariani et al. 1989), and 5-HT1d (Peroutka 1988) receptors are coupled to adenylyl cyclase inhibitory (Gi) proteins, while the 5-HT1c receptor is coupled to phospholipase C through a Gp protein (Conn et al. 1986).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Albert PA, Zhou Q-Y, Van Tol HHM, Bunzow JR, Civelli O (1990) Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene. J Biol Chem 265: 5825–5832
Ariani K, Hamblin MW, Tan GL, Stratford CA, Ciaranello RD (1989) G protein dependent alterations is [125I]-iodocyanopindolol and cyanopindolol binding at 5HT1b binding sites in rat brain membranes. Neurochem Res 14: 835–843
Bonner TI (1988) Cloning and expression of the human and rat M5 muscarinic acetylcholine receptor genes. Neuron 1: 403–410
Bonner TI, Buckley NJ, Young AC, Brann MR (1987) Identification of a family of muscarinic acetylcholine receptor genes. Science 237: 527–532
Conn PJ, Sanders-Bush E (1985) Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions. J Pharmacol Exp Ther 234: 195–203
Conn PJ, Sanders-Bush E, Hoffman BJ, Harting PR (1986) A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc Natl Acad Sci USA 83: 4086–4088
D’Amato RJ, Blue ME, Largent BL, Lynch DR, Ledbetter DJ, Molliver ME, Snyder SH (1987) Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas. Proc Natl Acad Sci USA 84: 4322–4326
Demuis A, Bouhelal R, Sebben M, Cory R, Bockaert J (1988) Nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol Pharmacol 34: 880–887
DeVivo M, Maayani S (1985) Inhibition of forskolin-stimulated adenylate cyclase activity by 5HT receptor agonists. Eur J Pharmacol 109: 231–234
Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ (1988) The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5HT1a receptor. Nature 335: 358–360
Julius D, MacDermott AB, Axel R, Jessel TM (1988) Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241: 558–564
Julius D, Huang KN, Livelli TJ, Axel R, Jessel TM (1990) The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci USA 87: 928–932
Lidov HGW, Molliver ME (1982) An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. Brain Res Bull 8: 389–430
Matsubara S, Meltzer HY (1989) Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex. Life Sci 45: 1397–1406
Palacios J, Waeber C, Mengod G, Hoyer D (1990) Visualization of serotonin receptor binding and their messenger RNAs in the mammalian brain: an update. In: Paoletti R, Vanhoutte PM, Brunello N, Maggi FM (eds) Serotonin: from cell biology to pharmacology and therapeutics. Elsevier, Amsterdam, pp 313–388
Pazos A, Cortes A, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in rat brain. II. Serotonin-2 receptors. Brain Res 34: 231–249
Peroutka SJ (1988) 5-Hydroxytryptamine receptor subtypes. In: Cowan WM, Shooter EM, Stevens CF, Thompson RF (eds) Annual review of neuroscience. Annual Reviews, Palo Alto, pp 45–60
Pritchett DB, Bach AW, Wozny M, Taleb O, Dal Toso R, Shih JC, Seeburg PH (1988) Structure and functional expression of cloned rat serotonin 5HT-2 receptor. EMBO J 7: 4135–4140
Roth BL, Chaung D-M (1987) Minireview: multiple mechanisms of serotonergic signal transduction. Life Sci 41: 1051–1064
Roth BL, Ciaranello RD (1992) Chronic mianserin treatment decreases 5-HT2 receptor binding without altering mRNA levels. Eur J Mol Pharmacol (1992)
Roth BL, Nakaki T, Chaung D-M, Costa E (1984) Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphoinositide turnover. Neuropharm acology 23: 1233–1225
Roth BL, McLean S, Zhu X-Z, Chaung D-M (1987) Characterization of two [3H]- ketanserin recognition sites in rat striatum. J Neurochem 49: 1833–1838
Roth BL, Hamblin MW, Ciaranello RD (1990) Regulation of serotonin receptors: methodology and mechanisms. Neuropsychopharmacology 3: 427–434
Roth BL, Hamblin MW, Ciaranello RD (1991) Developmental regulation of 5HT2 and 5HTlc mRNA and receptor levels. Dev Brain Res 58: 51–58
Sokoloff P, Giros B, Martres M-P, Bouthenet M-L, Schwartz J-C (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347: 147–151
Sunahara RK, Guan H-C, O’Dowd B, Seeman P, Laurier LG, Ng G, George Sr, Torchia J, Van Tol HM, Niznik HB (1991) Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than Dj. Nature 350: 614–619
Van Tol HHM, Bunzow JR, Guan H-C, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 611–614
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ciaranello, R.D. et al. (1993). Developmental Regulation of 5-HT2 and 5-HT1c Receptor Gene Expression in Rat Brain. In: Gram, L.F., Balant, L.P., Meltzer, H.Y., Dahl, S.G. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78010-3_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-78010-3_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-78012-7
Online ISBN: 978-3-642-78010-3
eBook Packages: Springer Book Archive