Abstract
A characteristic property of cytochrome P450 enzymes is their ability to react with a multitude of chemically very different substrates. Despite this fact, the basic mechanism of substrate oxygenation is the same for multiple forms and isozymes; it includes the energy-expensive process of molecular oxygen activation, splitting and formation of a very reactive oxygen species suited to oxidizing such chemically inert compounds as alkanes. The catalytic power of cytochrome P450 can be demonstrated by the thermodynamic parameters of the oxygenation process (Eq. 1).
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Rein, H., Jung, C. (1993). Metabolic Reactions: Mechanisms of Substrate Oxygenation. In: Schenkman, J.B., Greim, H. (eds) Cytochrome P450. Handbook of Experimental Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77763-9_7
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