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Sterol 26-Hydroxylase

  • Chapter
Cytochrome P450

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 105))

Abstract

26-Hydroxylated derivatives participate in several pathways of cellular metabolism. The 26-hydroxylation in bile acid biosynthesis has been studied extensively. A 26-hydroxylation is involved also in vitamin D3 metabolism. By virtue of being potent inhibitors of enzymes in cholesterol biosynthesis, some 26-hydroxylated sterol derivatives, such as 26-hydroxycholesterol, have been ascribed a role in regulation of sterol biosynthesis.

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  1. K. Wikvall
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Editors and Affiliations

  1. Department of Pharmacology, MC 1505, University of Connecticut Health Center, 263 Farmington Avenue, 06030, Farmington, CT, USA

    John B. Schenkman Ph.D.

  2. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landstr. 1, W-8042, Neuherberg, Fed. Rep. of Germany

    Helmut Greim M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Wikvall, K. (1993). Sterol 26-Hydroxylase. In: Schenkman, J.B., Greim, H. (eds) Cytochrome P450. Handbook of Experimental Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77763-9_46

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  • DOI: https://doi.org/10.1007/978-3-642-77763-9_46

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77765-3

  • Online ISBN: 978-3-642-77763-9

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