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Demyelinating and Degenerative Diseases

  • Chapter
MR Imaging of the Skull and Brain

Abstract

The diseases discussed in the following comprise a diverse set of conditions, most of which lead to a progressive decline in neurologic function. Many of these diseases are idiopathic, but others have known, for example, genetic or metabolic, foundations. While specific neuropathologic features may be seen in the demyelinating and some of the degenerative diseases, there is only nonspecific neuronal loss and accompanying reactive gliosis (often in a bilaterally symmetric fashion) in many other conditions. The neurologic picture resulting from these cerebral parenchymal alterations depends, of course, upon the site or sites of involvement. In broad terms, these sites may be considered as the basal ganglia and associated “extrapyramidal” structures, cerebral cortex, cerebellum and brainstem, and white matter. Although some conditions may involve more than one of these regions, classification will be according to the site of predominant involvement.

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  1. Dept. of Neuroradiology; Center for Neurological Diseases and Diseases of the Head and Neck (Kopfklinik), University of Heidelberg, Heidelberg, Germany

    Klaus Sartor M.D. (Professor of Neuroradiology, Director)

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Sartor, K. (1992). Demyelinating and Degenerative Diseases. In: MR Imaging of the Skull and Brain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75525-5_9

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