Skip to main content
SpringerLink
Log in

Persistent Maleic Acid Irritant Dermatitis in the Guinea Pig

  • Conference paper
Current Topics in Contact Dermatitis

Summary

Repeated exposure of guinea pig skin to maleic acid over a period of 8 months did not result in substantial irritant accommodation. Induction of dinitrochlorobenzene sensitivity was not facilitated by maleic acid irritant dermatitis but rather diminished. Chronically irritated guinea pig skin was acanthotic and showed hypergranulosis. Langerhans cell morphology was slightly altered with shorter and less numerous dendrites.

Based on work done at Emory University School of Medicine, Atlanta, GA, under NIOSH grant #R01-0H01124

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Bruynzeel DP, Maibach HI (1986) Excited skin syndrome (angry back). Arch Dermatol122: 323–328.

    Article  PubMed  CAS  Google Scholar 

  2. Colby SL, Artis WM, Rietschel RL (1983) Liposomes containing 3-n-pentadecylcatechol induce tolerance to toxicodendron. J Invest Dermatol 80: 145–149.

    Article  PubMed  CAS  Google Scholar 

  3. Friedlaender MH, Chisari FV, Baer H (1973) The role of the inflammatory response of skin and lymph nodes in the induction of sensitization to simple chemicals. J Immunol 111: 164–170.

    PubMed  CAS  Google Scholar 

  4. Lowney ED (1964) Topical hyposensitization of allergic contact sensitivity in the guinea pig. J Invest Dermatol 43: 487–490.

    PubMed  CAS  Google Scholar 

  5. Maurer T (1983) Contact and photocontact allergens. Marcel Dekker, New York, pp 51–52.

    Google Scholar 

  6. McOsker DE, Beck LW (1967) Characteristics of accommodated (hardened) skin. J Invest Dermatol 48: 372–383.

    PubMed  CAS  Google Scholar 

  7. Rietschel RL, Klemm J, Jones HE (1982) Chronic irritant dermatitis interferes with induction of dinitrochlorobenzene (DNCB) sensitization. Clin Res 30: 915A.

    Google Scholar 

  8. Rietschel RL, Klemm J, Thompson M (1982) The influence of accommodation (hardening) on the response to irritants, allergens, and mediators of inflammation in humans. Clin Res 30: 605A.

    Google Scholar 

  9. Robins PG, Brandon DR (1981) A modification of the adenosine triphosphatase method to demonstrate epidermal Langerhans cells. Stain Technol 56: 87–89.

    PubMed  CAS  Google Scholar 

  10. Uehara M, Ofuji S (1977) Suppressed cell-mediated immunity associated with eczematous inflammation. Acta Derm Venereol (Stockh) 57: 137–139.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA, 70121, USA

    R. L. Rietschel

Authors
  1. R. L. Rietschel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hautklinik der Universität Heidelberg, Voßstraße 2, 6900, Heidelberg 1, Germany

    Peter Frosch

  2. Department of Medical Research (Dermatology), Katholieke Universiteit Leuven, 3000, Leuven, Belgium

    A. Dooms-Goossens P.Ph., Ph.D.

  3. Unit and Laboratory of Occupational and Environmental Dermatology, Catholic University of Louvain, 30, Clos Chapelle-aux-Champs, UCL 3033, 1200, Brussels, Belgium

    J.-M. Lachapelle M. D. (Professor of Dermatology) (Professor of Dermatology)

  4. St. John’s Hospital for Diseases of the Skin, Lisle Street, London, WC2H 7BJ, Great Britain

    R. J. G. Rycroft

  5. Department of Pathology, Free University Hospital, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    R. J. Scheper

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Rietschel, R.L. (1989). Persistent Maleic Acid Irritant Dermatitis in the Guinea Pig. In: Frosch, P., Dooms-Goossens, A., Lachapelle, JM., Rycroft, R.J.G., Scheper, R.J. (eds) Current Topics in Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74299-6_87

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74299-6_87

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74301-6

  • Online ISBN: 978-3-642-74299-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation