Abstract
Calmodulin is an ubiquitous, small and acidic protein involved in calcium signal management in all eukaryotic cells (Van Eldik et al. 1982; Cox et al. 1984). The cell, when stimulated, transiently increases its cytosolic calcium concentrations from approximately 0.1 μM to 10 μM. In this range, calmodulin binds calcium ions, modifies its conformation and thereby modifies the function of calmodulin binding proteins. Therefore, calmodulin is a key element in the transduction of a quantitative calcium signal into a cellular response (Klee et al. 1980; Kilhoffer et al. 1983).
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© 1988 Springer-Verlag Berlin Heidelberg
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Haiech, J., Watterson, D.M. (1988). Site-Specific Mutagenesis and Protein Engineering Approach to the Molecular Mechanism of Calcium Signal Transduction by Calmodulin. In: Gerday, C., Bolis, L., Gilles, R. (eds) Calcium and Calcium Binding Proteins. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73042-9_14
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DOI: https://doi.org/10.1007/978-3-642-73042-9_14
Publisher Name: Springer, Berlin, Heidelberg
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