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Comparative Studies on Oncomodulin

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Calcium and Calcium Binding Proteins

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Oncomodulin is the name given to a calcium-binding protein of Mr 11700 kDa first noticed in 1979 in extracts of rat hepatomas (MacManus 1979), and later shown to be related, by comparison of amino acid sequences, to the β-parvalbumin subfamily of the large superfamily of calmodulin proteins (MacManus and Whitfield 1983; MacManus et al. 1983a,b). Many calcium-binding proteins have been described in tumour tissues, some, such as calmodulin or S100, increasing above the normal untransformed level (Watterson et al. 1976; MacManus et al. 1981; Isobe et al. 1984; Van Eldik et al. 1984), and others, such as protein A (Pfyffer et al. 1984) and oncomodulin, appearing de novo following neoplastic transformation. The primary structures of all these proteins are highly conserved. Calmodulin occurs in all eukaryotes with minimal sequence differences between those of protozoans, plants, invertebrates and vertebrates (including human) (Van Eldik et al. 1982; Roberts et al. 1985; Klee and Vana-man 1982). The parvalbumins are also conserved but restricted to vertebrates (Heizmann 1984).

NRC publication no. 28380

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Author information

Authors and Affiliations

  1. Cellular Oncology Group, Division of Biological Sciences, National Research Council of Canada, Ottawa, K1A OR6, Canada

    M. F. Gillen

Authors
  1. J. P. MacManus
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  2. L. M. Brewer
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  3. M. F. Gillen
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Editor information

Editors and Affiliations

  1. Laboratory of Muscle Biochemistry, Institute of Chemistry B6, University of Liège, Sart Tilman, 4000, Liège, Belgium

    Charles Gerday

  2. Institute of General Physiology, University of Messina, Via dei Verdi 85, 98100, Messina, Italy

    L. Bolis

  3. Laboratory of Animal Physiology, University of Liège, 22, quai Van Beneden, 4020, Liège, Belgium

    R. Gilles

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© 1988 Springer-Verlag Berlin Heidelberg

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MacManus, J.P., Brewer, L.M., Gillen, M.F. (1988). Comparative Studies on Oncomodulin. In: Gerday, C., Bolis, L., Gilles, R. (eds) Calcium and Calcium Binding Proteins. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73042-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-73042-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73044-3

  • Online ISBN: 978-3-642-73042-9

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