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Therapeutic Agents Affecting Body Temperature

  • Chapter
Pyretics and Antipyretics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 60))

Abstract

This chapter surveys the effects on mammalian thermoregulation of general anaesthetics, barbiturates, narcotic analgesics, and phenothiazines, all of which can produce increases as well as decreases in deep-body temperature. In addition to an account of the various factors which influence the degree or direction of temperature change produced by single drug administration, this review contains discussions of how repeated drug administration can give rise to tolerance and of the thermoregulatory changes which may be precipitated by withdrawal of drug treatment. There are also discussions of possible sites and mechanisms of action, of drug effects on heat gain and heat loss mechanisms and of drug interactions giving rise to hyperthermic responses. Drug effects on human thermoregulation have been discussed separately. However, as will be seen, the human data are in general agreement with results obtained in animal experiments.

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  1. Department of Pharmacology, University of Aberdeen, Marischal College, AB9 1AS, Aberdeen, Scotland, Great Britain

    Anthony S. Milton

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Pertwee, R.G. (1982). Therapeutic Agents Affecting Body Temperature. In: Milton, A.S. (eds) Pyretics and Antipyretics. Handbook of Experimental Pharmacology, vol 60. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68569-9_13

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