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Systemic Pharmacology of Adrenergic Activators and Inhibitors: Effects on the Respiratory System

  • Chapter
Adrenergic Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 54 / 2))

Abstract

This chapter is written as a general guide for the interested reader in the pharmacology of the respiratory system; thus, there are topics that necessarily overlap with the pharmacology of organs covered in other chapters. For example, the general stimulatory effect on respiration resulting from administration of toxic doses of most adrenergic activators is related to their central nervous system effects, as discussed in Chap. Sec. II B. A change in resistance to breathing in the upper respiratory tract is mediated by the pharmacologic effects of adrenergic activators on nasal blood vessels. This vascular phenomenon is pharmacologically related to behavior of the peripheral blood vessels, as discussed in Chap. Sec. III, Chap. 5. Any discussion of the pharmacology of the pulmonary circulation must include consideration of pulmonary blood flow or cardiac output, which is, in turn, dependent upon cardiac performance, as discussed in Chap. Sec. III, Chap. 5. More than three-quarters of the total clinical use of adrenergic drugs is in the treatment of diseases of the respiratory system. The pharmacologic basis for antiasthmatic drugs and cold remedies discussed in this chapter should supplement the clinical usage discussed in Chap. Sec. 5, Chap. 5. The remaining one-quarter of the clinical use of adrenergic inhibitors and activators (e.g., vasopressors, antihypertensives, antiarrhythmics, anorexigenics, antispasmodics) is also discussed in this chapter but additional details appear in Chap. Sec. 5, Chap. 5. Thus, these drugs may engender adverse reactions involving the respiratory system.

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  1. D. M. Aviado
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  2. M. S. Micozzi
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  1. Institute of Pharmacology, University Medical School of Szeged, Dóm tér 12, H-6701, Szeged, Hungary

    Lászlo Szekeres

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Aviado, D.M., Micozzi, M.S. (1981). Systemic Pharmacology of Adrenergic Activators and Inhibitors: Effects on the Respiratory System. In: Szekeres, L. (eds) Adrenergic Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 54 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67584-3_1

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