Abstract
Many in vitro models have been developed to predict the anti-inflammatory potency of newly synthesized compounds, but none of these methods is satisfactory. Glenn et al. (1973) stated bluntly: βAll of these in vitro methods are virtually useless for a predictive assessment of drugs in vivo. They are useful only after drugs are discovered in other systems.β The above statement was justified when in vitro methods relied entirely on non-specific interactions between non-steroid anti-inflammatory agents (NSAID) and a variety of proteins. However, it has been discovered that the target biomolecule for NSAID is fatty acid cyclo-oxygenase, a component of the prostaglandin (PG) synthetase system (Vane, 1971; Smith and Willis, 1971; Ferreira et al., 1971; see also Section C.III). Consequently, in vitro assessment of the inhibition of PG synthetase seems to be the rational approach for screening of compounds for their anti-inflammatory activity. The search for new NSAID of various chemical structures has been extensively reviewed (Shen, 1972; Scherrer and Whitehouse, 1974). In this chapter, the in vitro screening procedures for acidic NSAID will mainly be discussed.
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Gryglewski, R.J. (1979). Screening and Assessment of the Potency of Anti-Inflammatory Drugs in vitro. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_1
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