Summary
The blood-brain barrier in the rhesus monkey was opened reversibly by perfusing 2.2 mol/kg recrystallized DL-lactamide solution into the internal carotid artery. Gross neurologic sequelae did not occur and no changes were observed in brain water, sodium or potassium content 48 h after osmotic opening, demonstrating the nondestructive nature of such reversible opening. Prolonged barrier opening caused by perfusion of unrecrystallized lactamide, on the other hand, resulted in brain edema and electrolyte changes that were maximal 24–48 h later, consistent with entry of plasma water and salt into the brain. Barrier damage in this case was due presumably to a cytotoxic factor that could be removed by recrystallization. The results support the suggestion that a threshold intensity and duration of barrier opening is required to produce brain edema. Measurable edema may have been absent after reversible opening because interstitial albumin was excreted or metabolized by 48 h, or because a low brain compliance prevented significant water accumulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Aukland, K.: Editorial: Autoregulation of interstitial fluid volume: Edema-preventing mechanisms. Scand. J. clin. Lab. Invest. 31, 247–254 (1973)
Brightman, M.W., Hori, M., Rapoport, S.I., Reese, T.S., Westergaard, E.: Osmotic opening of tight junctions in the cerebral endothelium. J. comp. Neurol. 152, 317–325 (1973)
Clasen, R.A., Cooke, P.M., Pandolfi, S., Carnecki, G.: The effects of focal freezing on the central nervous system. Presbyterian St Luke Hosp. med. Bull. 2, 36–46 (1963)
Klatzo, I.: Pathophysiological aspects of brain edema. In: Reulen, H.J., Schürmann, K. (eds.). Steroids and Brain Edema. Berlin: Springer 1972, pp. 1–8
Landis, E.M., Pappenheimer, J.R.: Exchange of substances through capillary walls. In: Handbook of Physiology, Section 2: Circulation. Hamilton, W.F., Dow, P. ( eds.). Washington, D.C.: P. (eds.). 1963, Vol. II, pp. 961–1034
Lorenzo, A.V., Shirahige, I., Liang, M., Barlow, C.F.: Temporary alteration of cerebrovascular permeability to plasma protein during drug-induced seizures. Amer. J. Physiol. 223, 268–277 (1972)
Rapoport, S.I.: Modification of cerebrovascular permeability by hypertonic solutions and conditions which alter autoregulation of cerebral blood flow. In: Cervós-Navarro, J. et al. (eds.). The Cerebral Vessel Wall. New York: Raven Press 1976, pp. 215–223
Rapoport, S.I.: Blood-Brain Barrier in Physiology and Medicine. New York: Raven Press 1976
Rapoport, S.I., Hori, M., Klatzo, I.: Testing of a hypothesis for osmotic opening of the blood-brain barrier. Amer. J. Physiol. 223, 323–331 (1972)
Rapoport, S.I., Matthews, K., Thompson, H.K., Pettigrew, K.D.: Absence of brain edema after reversible osmotic opening of the blood-brain barrier. Sixth Ann. Meeting Soc. Neurosci., Abstr. no. 1067 (1976)
Rapoport, S.I., Thompson, H.K.: Osmotic opening of the blood-brain barrier in the monkey without associated neurological deficits. Science 180, 971 (1973)
Spatz, M., Rap, Z.M., Rapoport, S.I., Klatzo, I.: The effects of hypertonic urea on the blood-brain barrier and on the glucose transport in the brain. In: Reulen, H.J., Schürmann, K. (eds.) Steroids and Brain Edema. Berlin: Springer 1972, pp. 19–27
Starling, E.H.: On the absorption of fluids from the connective tissue spaces. J. Physiol. (Lond.) 19, 312–326 (1896)
Sun, C.L., Chiueh, C.C., Kopin, I.J., Fredericks, W.R., Rapoport, S.I.: Entry of 3-H-norepinephrine and 125I-albumin from blood into brain following osmotic opening of blood-brain barrier in the rat. Sixth Ann. Meeting Soc. Neurosci. Abstr. no. 731 (1976)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Rapoport, S.I., Matthews, K., Thompson, H.K. (1976). Absence of Brain Edema After Reversible Osmotic Opening of the Blood-Brain Barrier. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-66524-0_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-08009-1
Online ISBN: 978-3-642-66524-0
eBook Packages: Springer Book Archive