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Transport Properties of Capillaries Isolated From the Brain

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Dynamics of Brain Edema

Summary

Capillaries isolated from rat brain were used to study the blood-brain exchange of glucose and potassium at the cellular level. The uptake of glucose was saturable and stereospecific but not dependent upon energy. In contrast, the uptake of potassium was sensitive to ouabain and dependent upon oxygen. The high specific activity of the potassium transport system suggests that active ion transport may be a specialized function of brain capillaries and a vulnerable site in the pathogenesis of vasogenic brain edema. The retention of transport properties by this isolated capillary preparation indicates that it should be a useful tool in the study of brain edema.

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Authors and Affiliations

  1. Departments of Neurology and Pediatrics, University of California, School of Medicine, San Francisco, Calif., USA

    G. W. Goldstein & I. Diamond

Authors
  1. G. W. Goldstein
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  2. I. Diamond
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Editor information

Editors and Affiliations

  1. Dept. of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

  2. Montreal Neurological Institute, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

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© 1976 Springer-Verlag Berlin · Heidelberg

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Goldstein, G.W., Diamond, I. (1976). Transport Properties of Capillaries Isolated From the Brain. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-66524-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08009-1

  • Online ISBN: 978-3-642-66524-0

  • eBook Packages: Springer Book Archive

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