Summary
The microvascular reaction to focal cryogenic injury over the cerebral cortex in dogs and cats, examined by epicerebral fluorescein angiography and by measuring diameter changes in the epicerebral vessels, proceeds from an early phase of microcirculatory disturbance in the cortical capillaries and venules to a late phase of abnormal arterial circulation with arrest of microcirculation in the small cortical arteries below 100 μ in diameter, in capillaries, and in cortical veins. The changes of regional cerebral blood flow measured by beta-emitting krypton-85 correspond with fluorescein angiographic findings. On the other hand, the degree of change in the regional cerebral blood flow measured by gamma-emitting xenon-133 in the lesion does not correspond accurately with other findings due to error from “see-through” factors. The early microcirculatory disturbance and extensive aggregation of platelets in the small cerebral vessels, associated with preservation of the abnormal arterial circulation, may be an important factor in the pathogenesis of late wide-spreading brain edema after cryogenic injury to the cortex.
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Yamamoto, L., Soejima, T., Meyer, E., Feindel, W. (1976). Early Hemodynamic Changes at the Microcirculatory Level Following Focal Cryogenic Injury over the Cortex. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_11
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DOI: https://doi.org/10.1007/978-3-642-66524-0_11
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