Abstract
Occasionally ICP reduction can not be effected with conventional treatment modalities. Our approach in this situation has been to attempt to treat tissue metabolic-perfusion mismatching by reducing cerebral metabolic requirements (1). Barbiturates and hypothermia alone or in combination can reduce brain metabolism (2), cerebral blood flow (2), intracranial pressure (3), and the size of cerebral infarction after middle cerebral artery occlusion (4).
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SHAPIRO, H.M., WYTE, S.R., LOESER, J.: Barbiturate-augmented hypothermia for reduction of persistant intracranial hypertension. J. Neurosurg. 40, 90–100 (1974).
SMITH, A.L., WOLLMAN, H.: Cerebral blood flow and metabolism. Anesthesiology 36, 378–400 (1972).
SHAPIRO, H.M., GALINDO, A., WYTE, S.R., HARRIS, A.B.: Rapid reduction of intracranial pressure with thiopentone. Brit. J. Anaesth. 45, 1057–1062 (1973).
SMITH, A.L., HOFF, J.T., NIELSEN, S.L., LARSON, C.P.: Barbiturate protection in acute focal ischemia. Stroke 5, 1–7 (1974).
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© 1975 Springer-Verlag Berlin Heidelberg
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Shapiro, H.M., Wyte, S.R., Loeser, J.D. (1975). Barbiturates and Hypothermia for Persistently Increased Intracranial Pressure. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_78
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DOI: https://doi.org/10.1007/978-3-642-66086-3_78
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