Abstract
Neurogenic pulmonary edema (NPE) occurs unpredictably in patients with brain injury. In the laboratory, hypothalamic and medullary lesions, increased intracranial pressure (ICP), cerebral trauma and subarachnoid instillation of various irritants have all produced NPE. Despite these studies, the etiology of NPE in man remains unclear, the physiology poorly understood, and the appropriate treatment unknown. In dogs with increased ICP, we sought to define cardio pulmonary abnormalities associated with NPE and to find possible approaches to prevent or treat NPE. Despite marked changes in physiologic parameters evoked by increased ICP, pulmonary edema developed in only 2 of 31 animals. On the basis of these experiments we have concluded that elevated ICP is not the essential stimulus for NPE.
This research was supported in part by USPHS Training Grant NINDS 5593, Anesthesia Program project Grant 15571, Trauma Center Grant GM 18470, and CVRI Grant HL 06285.
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Pitts, L.H., Severinghaus, J.W., Mitchell, R.A., Hoff, J.T. (1975). The Role of Increased Intracranial Pressure in the Production of Neurogenic Pulmonary Edema. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_68
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DOI: https://doi.org/10.1007/978-3-642-66086-3_68
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