Abstract
The effects of an arterial hemorrhage into the subarachnoid space are to a considerable extent reversible and survivable. The mechanisms responsible have been analyzed experimentally (1). When bleeding starts, intracranial counterpressure develops rapidly. The reduction in the rate of bleeding permits spontaneous hemostasis to take place. The dangerously high intracranial pressure (ICP) is reduced within minutes to the normal level by means of a spatial compensation effected by an increased outflow of cerebrospinal fluid (CSF). During the period of high pressure, cerebral blood flow (CBF) is maintained by an autoregulatory response (2). The tolerance to repeated hemorrhagic insults and the mechanisms limiting this tolerance have recently been analyzed experimentally in this laboratory(3,4).
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References
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Löfgren, J., Steiner, L., Zwetnow, N.N. (1975). Intracranial Pressure Course in Repeated Subarachnoid Hemorrhage. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_23
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DOI: https://doi.org/10.1007/978-3-642-66086-3_23
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