Abstract
During the advanced stage of intracranial hypertension, plateau waves are sometimes observed, which are accompanied by dilatation of cerebral vessels (1) and decrease in cerebral blood flow (2). The rich adrenergic nerve supply of the cerebral blood vessels (3) suggests that pressor amines possibly affect the cerebral circulation and the cerebral vascular tone. It has been reported that monoamine metabolism in the brain tissue changes during experimentally induced intracranial hypertension (4). This study is to investigate the effects of norepinephrine and phentolamine on intracranial pressure and to clarify the mechanism producing the plateau waves.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
LUNDBERG, N.: Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiat. Neurol. Scand. 36, suppl. 149 (1960).
LASSEN, N.A., HØEDT-RASMUSSEN, K., SØRENSEN, S.C., SKINHØJ, E., BODFORSS, B., INGVAR, D.H.: Regional cerebral blood flow in man determined by Krypton85. Neurology (Minneap.) 13, 719–727 (1963).
NIELSEN, K.C., OWMAN, Ch.: Adrenergic innervation of pial arteries related to the cicle of Willis in the cat. Brain Res. 6, 773–776 (1967).
EDVINSON, L., OWMAN, Ch., ROSENGREN, E., WEST, K.A.: Brain concentration of dopamine, noradrenaline, 5-hydroxytryptamine, and homovanillic acid during intracranial hypertension following traumatic brain injury in rabbit. Acta Neurol. Scand. 47, 458–463 (1971).
LANGFITT, T.W., WEINSTEIN, J.D., KASSELL, N.F.: Cerebral vasomotor paralysis produced by intracranial hypertension. Neuroloay (Minneap.) 15, 622–641 (1965).
NIELSEN, K.C., OWMAN, Ch., SPORRONG, B.: Ultrastructure of the autonomic innervation in the main pial arteries of the rats and cats. Brain Res. 27, 25–32 (1971).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hayashi, M., Fujii, H., Marukawa, S., Kitano, T., Yamamoto, S. (1975). Effects of Norepinephrine and Phentolamine on Increased Intracranial Pressure. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_101
Download citation
DOI: https://doi.org/10.1007/978-3-642-66086-3_101
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66088-7
Online ISBN: 978-3-642-66086-3
eBook Packages: Springer Book Archive