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Effect of Antioxidants on Experimental Cold-Induced Cerebral Edema

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Steroids and Brain Edema

Summary

Cerebral edema was produced by local cortical freezing in untreated and treated animals. Treated animals received p-Ethoxyphenol (pEOP) and N,N′-diphenyl-p-phenylenediamine (DPPD). A daily dose of 100 mg/kg in pre-treated animals and 500 mg/kg of DPPD in post-injured animals showed a significant reduction in cerebral edema as demonstrated in gross and coronal specimens, histologic study and differences in white matter weights. A similar dose of 100 mg/kg of DPPD given 1 h after injury was ineffective, while a large dose of 1000 mg/kg was lethal in this experimental model. The effect of pEOP was not significant. The beneficial effect of DPPD, an antioxidant, is postulated to be in the prevention or inhibition of free radical peroxidative mechanisms. It is postulated that membrane lipids may be the principle molecules undergoing free radical damage. The hypothesis is advanced that steroids, by intercalating into membranes in a specific configuration may prevent the radical initiation and chain reactions that damage the fatty acids of membrane phospholipids. The molecular mechanism of cerebral edema is harmonious with other mechanisms that are at the cellular and subcellular level.

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Authors and Affiliations

  1. Departments of Neurosurgery and Pathology, New York University Medical Center, New York, NY, 10010, USA

    Bienvenido D. Ortega, Harry B. Demopoulos & Joseph Ransohoff

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  1. Bienvenido D. Ortega
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  1. Neurochirurgische Universitätsklinik Mainz, 6500, Mainz, Langenbeckstr. 1, W. Germany

    H. J. Reulen  & K. Schürmann  & 

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Ortega, B.D., Demopoulos, H.B., Ransohoff, J. (1972). Effect of Antioxidants on Experimental Cold-Induced Cerebral Edema. In: Reulen, H.J., Schürmann, K. (eds) Steroids and Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65448-0_19

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  • DOI: https://doi.org/10.1007/978-3-642-65448-0_19

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