Abstract
The subject of brain edema (BE) has been burdened for many years by confusion with regard to understanding the essential pathophysiological aspects of the process. Various classifications were based mainly either on some gross characteristics, such as Reichardt’s [29] Hirnödem v. Hirnschwellung, or on etiological factors involved (e.g. traumatic, inflammatory, necrotic, hemorrhagic, etc.), which contributed only some limited descriptive value.
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References
Aleu, F. P., Katzman, R., Terry, R. D.: Fine structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication. J. Neuropath, exp. Neurol. 22, 403 (1963).
Bakay, L., Bendixen, H. H.: Central nervous system vulnerability in hypoxic states: Isotope uptake studies. In: Selective Vulnerability of the Central Nervous System in Hypoxaemia. McMenemey, W. H., Schade, J. F. (Eds.), Oxford: Blackwell Scient. Publ. p. 63, 1963.
Brightman, M. W.: The intracerebral movement of proteins injected into blood and cerebrospinal fluid of mice. In: Brain Barrier Systems. Lajtha, A., Ford, D. H. (Eds.) Progress in Brain Research, Vol. 29, pp. 19–37, Amsterdam: Elsevier 1968.
Brightman, M. W., Reese, T. S.: Junctions between intimately apposed cell membranes in the vertebral brain. J. Cell Biol. 40, 648–677 (1969).
Bulle, P. H.: Effects of reserpine and chlorpromazine in prevention of cerebral edema and reversible cell damage. Proc. Soc. exp. Biol. 94, 553–556 (1957).
Gonatas, N. K., Zimmerman, H. M., Levine, S.: Ultrastructure of inflammation with edema in the rat brain. Amer. J. Path. 42, 455–469 (1963).
Gump, W. S.: Toxicological properties of hexachlorophene. J. Soc. Cosmetic Chemists 20, 173–184 (1969).
Haddy, F. J.: The mechanism of edema production by acetylcholine, serotonin, histamine and norepinephrine. Fed. Proc. 19, 93 (1960).
Hirano, A., Zimmerman, H. M., Levine, S.: The fine structure of cerebral fluid accumulation. III. Extracellular spread of cryptococcal polysaccharides in the acute stage. Amer. J. Path. 45, 1–19 (1964).
Hirano, A., Zimmerman, H. M., Levine, S.: Fine structure of cerebral fluid accumulation. X. A review of experimental edema in the white matter. In: Klatzo, I., Seitelberger, F. (Eds.) Brain Edema, pp. 569–589, Berlin-Heidelberg-New York: Springer 1967.
Hossmann, K. A., Olsson, Y.: Suppression and recovery of neuronal function in transient cerebral ischemia. Brain Res. 22, 313–325 (1970).
Johansson, B., Li, C. L., Olsson, Y., Klatzo, I.: The effect of acute arterial hypertension on the blood-brain barrier to protein tracers. Acta neuropath. (Berl.) 16,117–124 (1970).
Kimbrough, R. D., Gaines, T. B. Hexachlorophene effects on the rat brain. Study of high doses by light and electron microscopy. Arch. Environmental Health 23, 114–118 (1971).
Klatzo, I.: Neuropathological aspects of brain edema; Presidential address. J. Neuropath, exp. Neurol. 26, 1–14 (1967).
Klatzo, I., Wisniewski, H., Steinwall, O., Streicher, E.: Dynamics of cold injury edema. In: Klatzo, I., Seitelberger, F. (Eds.) Brain Edema, pp. 554–563, Berlin-Heidelberg-New York: Springer 1967.
Lampert, P., Carpenter, S.: Electron microscopic studies on the vascular permeability and the mechanism of demyelination in experimental allergic encephalomyelitis. J. Neuropath, exp. Neurol. 24, 11–24 (1965).
Lampert, P., Garro, F., Pentschew, A.: Lead encephalopathy in suckling pigs. In: Klatzo, I. Seitelberger, F. (Eds.) Brain Edema, pp. 413–425, Berlin-Heidelberg New York: Springer 1967.
Lee, J. C, Bakay, L.: Ultrastructural changes in the edematous central nervous system. I. Triethyl tin edema. Arch. Neurol 13, 48–57 (1965).
Lee, J. C, Bakay, L.: Ultrastructural changes in the edematous central nervous system. II. Cold induced edema. Arch. Neurol. 14, 36–9 (1966).
Majno, G., Palade, G. E.: Studies on inflammation. I. The effect of histamine and serotonin on vascular permeability: An electron microscopic study. J. biophys. biochem. Cytol. 11, 571–605 (1961).
Majno, G., Shea, S. M., Leventhal, M.: Endothelial contraction induced by histamin-type mediators; an electron microscopic study. J. Cell Biol. 42, 647–672 (1969).
Misra, S. S., Singh, K. S. P., Ghargava, K. P.: Estimation of 5-hydroxytryptamine (5 HT) level in cerebrospinal fluid of patients with intracranial or spinal lesions. J. Neurol. Neurosurg. Psychiatr. 30, 163–165 (1967).
Mossakowski, M. J., Long, D. M., Myers, R. E., Rodriguez, H., Klatzo, I.: Early histochemical changes in perinatal asphyxia. J. Neuropath, exp. Neurol. 27, 500–516 (1968).
Olsson, Y., Hossmann, K. A.: Vulnerability of the blood-brain barrier (BBB) to proteins after cerebral ischemia. J. Neuropath, exp. Neurol. 29, 125 (1970).
Olsson, Y., Crowell, R. M., Klatzo, I.: The blood-brain barrier to protein tracers in focal cerebral ischemia and infarction caused by occlusion of the middle cerebral artery. Acta Neuropath. (Berl.) 18, 89–102 (1971).
Osterholm, J. L., Bell, J., Myer, R., Pyenson, J.: Experimental effects of free serotonin on the brain and its relation to brain injury. Part I: The neurological consequences of intracerebral serotonin injections. Part 2: Trauma induced alterations in spinal fluid and brain. Part 3: Serotonin induced cerebral edema. J. Neurosurg. 31, 408–421 (1969).
Rapoport, S. T., Hori, M., Klatzo, I.: Reversible osmotic opening of the blood-brain barrier. Science 173, 1026–1028 (1971).
Reese, T. S., Karnovsky, M. J.: Fine structural localization of the blood-brain barrier to exogenous peroxidase. J. Cell. Biol. 34, 207–217 (1967).
Reichardt, M.: Zur Entstehung des Hirndrucks. Dtsch. Z. Nervenheilk. 28, 306 (1904).
Sachs, E., Jr.: Acetylcholine and serotonin in the spinal fluid. J. Neurosurg. 14, 22–27 (1957).
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Klatzo, I. (1972). Pathophysiological Aspects of Brain Edema. In: Reulen, H.J., Schürmann, K. (eds) Steroids and Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65448-0_1
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DOI: https://doi.org/10.1007/978-3-642-65448-0_1
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