Abstract
The occurrence of metastasis requires detachment of metastatic tumor cells or the primary tumor. It is known that lost of several adhesion molecules by cels of the primary tumor is involved in this event, for example, E-cadherin in carcinomas (Frixen et al. 1991) and α4 integrin in melanomas (Qian et al. 1994). Migrating metastatic cells enter the blood vasculature or the lymphatics through which they are transported to peripherical organs. In the periphery the cells must adhere in some way to the vascular endothelium before they can extravasate and form a secondary tumor. This chapter describes the adhesion molecules α6 and αv integrins and shows at what point they are involved in the adhesion and migration of metastatic tumor cells.
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© 1996 Springer-Verlag Berlin Heidelberg
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Imhof, B.A., Piali, L., Gisler, R.H., Dunon, D. (1996). Involvement of α6 and αv Integrins in Metastasis. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation I. Current Topics in Microbiology 213/I and Immunology, vol 213/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61107-0_12
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DOI: https://doi.org/10.1007/978-3-642-61107-0_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64697-3
Online ISBN: 978-3-642-61107-0
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