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Outer Membrane Protein Vaccines

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Vaccines

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 133))

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Abstract

Bacterial vaccines that are used on a large-scale are composed of killed or attenuated whole cells, toxoids, and polysaccharide-protein conjugate vaccines. Examples of such vaccines for human use include diphtheria, pertussis, tetanus, bacille Calmette-Guérin, Haemophilus influenzae type b conjugates, cholera, and typhoid. New subunit pertussis vaccines have recently been registered which in addition to pertussis toxoid may contain surface proteins such as filamentous hemagglutinin (FHA) and pertactin. FHA and pertactin are the first two bacterial surface proteins to become part of widely accepted vaccines.

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  1. The Wenner-Gren Institute Department of Immunology The Arrhenius Laboratories F5, Stockholm University, S-106 91, Stockholm, Sweden

    Peter Perlmann (Professor) (Professor)

  2. MTC, Karolinska Institute, S-171 77, Stockholm, Sweden

    Hans Wigzell (Professor) (Professor)

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Poolman, J. (1999). Outer Membrane Protein Vaccines. In: Perlmann, P., Wigzell, H. (eds) Vaccines. Handbook of Experimental Pharmacology, vol 133. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59955-2_9

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