Abstract
Nowadays, a broad spectrum of prenatal tests are available for pregnant women to assure the well-being of the unborn child. The various methods fall into two groups: the non-invasive and the invasive procedures. Here only the latter, namely amniocentesis, chorionic villi sampling and fetal blood sampling, should be considered. Tissue sampling is performed under sonographic control by specialized gynecologists who provide the specimen for genetic analysis. Importantly, all invasive techniques carry a significant procedure-related risk for an abortion.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bauer-Hansmann D, Golbus MS (1993) Prenatal diagnosis. In: Stevenson RE, Hall JG, Goddman RM (eds) Human malformations and related anomalies Vol I, Oxford University Press, New York, Oxford.
Canadian collaborative CVS-amniocentesis clinical trial group (1989) Multicentre randomised clinical trial of chorionic villi sampling and amniocentesis. Lancet I: 1–6.
Daffos F (1991) Fetal blood sampling. In Harrison MR, Golbus MS, Filly RA (eds), The unborn patient. Saunders, Philadelphia.
DeLozier-Blanchet CD, Pellegrini B, Hahnemann JM, Pampallona S, Vejerslev LO (1997) The impact of CPM on fetal growth and development. Data from EUCROMIC (Abstract). 1st post EUCROMIC satellite meeting on prenatal diagnosis. Genova.
Hahnemann JM, Vejerslev LO (1997) European collaborative research on mosaicism in CVS (EUCROMIC): fetal and extrafetal cell lineages in 192 gestations with CVS mosaicism involving single autosomal trisomy. Am J Med Genet 70: 179–187.
Hsu LYF, Perlis TE (1984) United States survey on chromosome mosaicism and pseudomosaicism in prenatal diagnosis. Pren Diagn 4: 97–130.
Kennerknecht I, Barbi G, Wolf M, Djalali M, Grab D, Terinde R, Vogel W (1993) Cytogenetic diagnosis after chorionic villus sampling are less reliable in very-high-and very-low-risk pregnancies. Pren Diagn 13: 929–944.
Kulier AM, Modell B, Jackson L, Simpson JL, Brambati B, Rhoads G, Froster U, Verlinsky Y, Smidt-Jensen S, Holzgreve W et al. (1993) Risk evaluation of CVS. Prenat Diagn 13: 197–209.
Lippman A, Tomkins DJ, Shime J, Hamerton JL, and Canadian Collaborative CVS-Amniocentesis clinical trial group (1992) Canadian multicentre randomized clinical trial of chorionic villus sampling and amniocentesis. Final report. Pren Diagn 12: 385–476.
MRC Working Party on the evaluation of chorionic villus sampling (1991) Medical Research Council European Trial of chorionic villus sampling. Lancet 337: 1491–1499.
Nicolini U, Rodeck CH (1992) Fetal blood and tissue sampling. In Brock, Rodeck, Ferguson-Smith (eds) Prenatal diagnosis and screening, Livingstone, Edinburgh.
Smidt-Jensen S, Permin M, Philip J, Lundsteen C, Zachary JM, Fowler SE, Gruning K (1992) Randomized comparison of amniocentesis and transabdominal and transcervical chorionic villus sampling. Lancet 340: 1238–1244.
Tabor A, Madsen M, Obel EB, Philip J, Bang J, Noergard-Peterson B (1996) Randomized controlled trial of genetic amniocentesis in 4606 low-risk women. Lancet I:1287–1293.
Wegner RD (1993) Chorionic villi analysis. In Obe G (ed) Advances in mutagenesis research 4. Springer Verlag Berlin, Heidelberg, New York.
Wilson RD (1995) Early amniocentesis: a clinical review. Pren Diagn 15: 1259–1273
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wegner, RD. (1999). Prenatal Diagnosis — An Introduction. In: Wegner, RD. (eds) Diagnostic Cytogenetics. Springer Lab Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59918-7_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-59918-7_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-47813-0
Online ISBN: 978-3-642-59918-7
eBook Packages: Springer Book Archive