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Herpes Viral Proteins Blocking the Transporter Associated with Antigen Processing TAP — From Genes to Function and Structure

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Viral Proteins Counteracting Host Defenses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 269))

Abstract

In adaptation to the immune system, viruses have developed manifold mechanisms to evade the immune response, causing lifelong persistence in the host. Several members of the herpesvirus family are known to interfere with antigen presentation via MHC class I molecules. Here we compare the mechanistic and structural aspects of two unrelated herpesviral proteins, both of which have selected the transporter associated with antigen processing (TAP) as target for immune evasion. However, ICP47 (IE12) encoded by the herpes simplex virus and US6 from human cytomegalovirus utilize entirely different strategies to block TAP function. Detailed knowledge of the function and structure of these viral factors will help to understand TAP function and to design novel immune suppressors or vectors for gene transfer.

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Authors and Affiliations

  1. Institute of Biochemistry, Biozentrum Frankfurt, Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439, Frankfurt, Germany

    D. Bauer & R. Tampé

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  1. D. Bauer
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  2. R. Tampé
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Editors and Affiliations

  1. Max von Pettenkofer Institute, University of Munich, Pettenkoferstr. 9a, 80336, Munich, Germany

    Ulrich H. Koszinowski

  2. Robert Koch-Institut, Fachgebiet 1.2 Virale Infektionen, Nordufer 20, 13353, Berlin, Germany

    Hartmut Hengel

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Bauer, D., Tampé, R. (2002). Herpes Viral Proteins Blocking the Transporter Associated with Antigen Processing TAP — From Genes to Function and Structure. In: Koszinowski, U.H., Hengel, H. (eds) Viral Proteins Counteracting Host Defenses. Current Topics in Microbiology and Immunology, vol 269. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59421-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-59421-2_6

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  • Print ISBN: 978-3-642-63974-6

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