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Viral Chemokine Receptors and Chemokines in Human Cytomegalovirus Trafficking and Interaction with the Immune System

  • Chapter
Viral Proteins Counteracting Host Defenses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 269))

Abstract

The ubiquitous, opportunistic pathogen human cytomegalovirus (CMV) encodes several proteins homologous to those of the host organism. Four different CMV genes encode chemokine receptor-like peptides. These genes, UL33, UL78, US27, and US28, are expressed at various stages of infection in vitro. Their functions remain largely unknown. To date, chemokine binding and signalling has only been demonstrated for the US28 gene product. Putative ligands for the other CMV-encoded chemokine receptors are discussed on basis of phylogenetic analysis. The potential roles of these receptors in virus trafficking, persistence, and immune evasion are summarized. Similarly, modulation of expression of the host chemokines IL-8, MCP-1, MIP-la and RANTES in relation to viral dissemination and persistence is reviewed.

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Authors and Affiliations

  1. Unité d’Immunologie Virale, Institut Pasteur, 28 Rue du Docteur Roux, 75274, Paris Cedex 15, France

    P. S. Beisser & S. Michelson

  2. Program in Medical Information Sciences, University of California, San Francisco, CA, 94143, USA

    C.-S. Goh & F. E. Cohen

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  1. P. S. Beisser
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  2. C.-S. Goh
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  3. F. E. Cohen
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  4. S. Michelson
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Editors and Affiliations

  1. Max von Pettenkofer Institute, University of Munich, Pettenkoferstr. 9a, 80336, Munich, Germany

    Ulrich H. Koszinowski

  2. Robert Koch-Institut, Fachgebiet 1.2 Virale Infektionen, Nordufer 20, 13353, Berlin, Germany

    Hartmut Hengel

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Beisser, P.S., Goh, CS., Cohen, F.E., Michelson, S. (2002). Viral Chemokine Receptors and Chemokines in Human Cytomegalovirus Trafficking and Interaction with the Immune System. In: Koszinowski, U.H., Hengel, H. (eds) Viral Proteins Counteracting Host Defenses. Current Topics in Microbiology and Immunology, vol 269. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59421-2_13

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  • DOI: https://doi.org/10.1007/978-3-642-59421-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63974-6

  • Online ISBN: 978-3-642-59421-2

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