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Melissa officinalis L. (Lemon Balm): In Vitro Culture and the Production and Analysis of Volatile Compounds

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Medicinal and Aromatic Plants V

Part of the book series: Biotechnology in Agriculture and Forestry ((AGRICULTURE,volume 24))

Abstract

The genus Melissa belongs to the family Labiatae (Lamiaceae) and comprises erect branched herbs with crenate opposite leaves and a two-lipped corolla. It includes very few species, which chiefly occur in many parts of Europe and Asia. For the European region two individual species are differentiated by the Flora Europaea (Tutin et al. 1972): M. officinalis L. (comprising the two subspecies officinalis and altissima (Sibth. & Sm.) Arcangeli, and M. bicornis Klokov, which may be identical with the subspecies altissima.

Dedicated to Prof. O.L. Lange (University of Würzburg) on the occasion of his 65th birthday

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References

  • Abou-Mandour AA (1982) Untersuchung an Ruta graveolens ssp. divaricata. 1 Mitteilung:Anlage und Anzucht von Kalluskult’uren und Induktion von Sproßregeneraten. Planta Med 46:105–109

    Article  PubMed  CAS  Google Scholar 

  • Auf’mkolk M, Ingbar JC, Amir SM, Winterhoff H, Sourgens H, Hesch RD, Ingbar SH (1984a) Inhibition of certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology 1152:527–534

    Article  CAS  Google Scholar 

  • Auf’mkolk M, Koehrle J, Gumbinger H, Winterhoff H, Hesch RD (1984b) Antihormonal effects of plant extracts: iodothyronine deiodinase of rat liver is inhibited by extracts and secondary metabolites of plants. Horm Metabol Res 164:188–192

    Article  Google Scholar 

  • Basker D, Putievsky E (1978) Seasonal variation in the yields of herb and essential oil in some Labiatae species. J Hortic Sci 53(3): 179–183

    Google Scholar 

  • Bos R, Kutter L, Friedrich H (1987) Volatile constituents of the underground parts of Melissa officinalis L. Abstr 18th Int Symp on Essential Oils, Leiden, Netherlands, p. 26

    Google Scholar 

  • Brieskorn CH, Krause W (1974) Weitere Triterpene aus Melissa officinalis L. Arch Pharm 307:603–612

    Article  CAS  Google Scholar 

  • Brieskorn CH, Briner M, Schlumprecht L, Eberhardt KH (1952) Vergleichende quantitative Bestimmungen der Ursolsäure und des ätherischen Ö1s in pharmazeutisch-und lebensmittelchemisch-wichtigen Labiaten. Arch Pharm 285:290–296

    Article  CAS  Google Scholar 

  • Brieskorn CH, Eberhardt KH, Briner M (1953) Biogenetische Zusammenhange zwischen Oxytriterpen-sauren und ätherischem Öl bei einigen pharmazeutisch wichtigen Labiaten. Arch pharm 286:501–506

    Article  CAS  Google Scholar 

  • Brown JT, Hegarty PK, Charlwood BV(1987) The toxicity of monoterpenes to plant cell cultures. Plant Sci 48:195–201

    Article  CAS  Google Scholar 

  • Butcher DN, Connolly JD (1971) An investigation of factors which influence the production of abnormal terpenoids by callus cultures of Andographis paniculata Nees. J Exp Bot 22:314–322

    Article  CAS  Google Scholar 

  • Cadeac, Meunier cited according to Braun H (1964) Die aktuelle Arzneipflanze: Melissa officinalis-Melisse. Z Ther 2:297–302

    Google Scholar 

  • Charlwood BV, Charlwood KA (1991) Terpenoid production in plant cell cultures. In: Harborne JB, Tomas-Barberan FA (eds) Ecological chemistry and biochemistry of plant terpenoids. Clarendon Press, Oxford, pp 95–132

    Google Scholar 

  • Chlabicz J, Galasinski W (1986) The components of Melissa officinalis L. that influence protein biosynthesis in vitro. J Pharm Pharmacol 38:791–794

    Article  PubMed  CAS  Google Scholar 

  • Chlabicz J, Rosanski A, Galasinski W (1984) Studies on substances of plant origin with anticipated cyto-and oncostatic activity. Part 1. The influence of water extracts from Melissa officinalis on the protein biosynthesis in vitro. Pharmazie 39(11): 770

    PubMed  CAS  Google Scholar 

  • Chopra RN, Nayar SL, Chopra IC (1956) Glossary of Indian medicinal plants. Council of Scientific and Industrial Research, New Delhi, p 164

    Google Scholar 

  • Cohen, RA, Kucera LS, Herrmann EC (1964) Antiviral activity of Melissa officinalis (lemon balm) extract. Proc Soc Exp Biol Med 117:431–434

    PubMed  CAS  Google Scholar 

  • Dawson BSW, Franich RA, Meder R (1988) Essential oil of Melissa officinalis L. subsp. altissima (Sibthr et Smith) Arcang Flavour Fragrance J 3:167–170

    Article  Google Scholar 

  • Debelmas AM, Rochat J (1967) Pharmacologic study of essential oils; antispasmodic activity of fifty samples. Plant Med Phytother l1:23–27

    Google Scholar 

  • Deininger R (1984a) Neues aus der Terpenforschung (etherische Öle und Inhaltsstoffe). Excerpta Phytotherapeutica; Vorträge auf dem Ärztekongress Berlin, 12–16 June, 1984, pp 24–31

    Google Scholar 

  • Deininger R (1984b) Neues aus der Terpenforschung. Der Kassenarzt Deutsches Ärztemagazin 124–18

    Google Scholar 

  • Deininger R (1985) Neues aus der Terpenforschung. Der Kassenarzt Deutsches Ärzternagazin 7:47–56

    Google Scholar 

  • Delpy H (1910) Beiträge zur Kenntnis arzneilich verwendeter Labiaten 6 Melissa officinalis L. Z Allg Öster Apoth Ver 48 32:317–318

    Google Scholar 

  • Dikshit A, Husain A (1984) Antifungal action of some essential oils against animal pathogens. Fitoterapia 55 3:171–176

    CAS  Google Scholar 

  • Dombrowicz E, Broda B (1973) Badania chemiczne slum owocow niektorych gatunkow z rodziny Labiatae. Farm Polska 29 2:163–168

    CAS  Google Scholar 

  • Dorner WG (1983) Dtsch Apoth 35:559

    Google Scholar 

  • Dorner WG (1985) Die Melisse — immer noch zu Überraschungen fähig. Pharm Unserer Zeit 14:112–121

    Article  PubMed  CAS  Google Scholar 

  • Engler A, Prantl K (1889) Die natürlichen Pflanzenfamilien. Wilhelm Engelmann, Leipzig 6:295–296

    Google Scholar 

  • Enjalbert F, Bessiere JM, Pellecuer J, Privat G (1983) Analyse des essences de melisse. Fitoterapia 1983 2:59–65

    Google Scholar 

  • Franke W (1978) On the contents of vitamin C and thiamin during the vegetation period in leaves of three spice plants (Allium schoenoprasum L., Melissa officinalis L., and Petroselinum crispum (Mill.) Nym. ssp. crispum). Acta Hortic. 73:205–212

    Google Scholar 

  • French D, Youngquist YA, Lee A (1959) Isolation and crystallization of planteose from mint seeds. Arch Biochem Biophys 85:471–473

    Article  PubMed  CAS  Google Scholar 

  • Gbolade AA, Lockwood GB (1989) The constituents of Melissa officinalis cell cultures. Planta Med 55:228

    Article  Google Scholar 

  • Gbolade AA, Lockwood GB (1991a) The constituents of Melissa officinalis L. cultures. J Ess Oil Res 3:111–114

    Article  CAS  Google Scholar 

  • Gbolade AA, Lockwood GB (1991b) Growth and production of volatile substances by Melissa officinalis and Petroselinum crispum cultures. Fitoterapia 62:237–242

    CAS  Google Scholar 

  • Gordonoff T (1969) Über die Pharmakologie der Karminativa. Hippokrates 31 1:335–338

    Google Scholar 

  • Gurka D, Farnham I, Potter BB, Pyle S, Titus R, Duncan W (1989) Quantitation capability of a directly linked gas chromatography/Fourier transform infrared/ mass spectrometry system. Anal Chem 61:1584–1589

    Article  CAS  Google Scholar 

  • Haragsimova L (1963) Effect produced in vitro on Bacillus larvae by inhibitors of plant origin. Ved Pr Vzyk Ustavu Vcelar Skebo 3:13-52 cited according to CA 65:1076a (1966)

    Google Scholar 

  • Hefendehl FW (1970) Zusammensetzung des ätherisehen Ö1s von Melissa officinalis L. und sekundäre Veränderungen der Ölkomposition. Arch Pharm 303:345–357

    Article  CAS  Google Scholar 

  • Herres W (1987) HRGC-FTIR: capillary gas chromatography Fourier transform infrared spectroscopy. theory and applications. Hüthig Verlag. Heidelberg

    Google Scholar 

  • Herrmann EC, Kucera LS (1967) Antiviral substances in plants of the mint family (Labiatae). II. Nontannin polyphenol of Melissa officinalis. Proc Soc Exp Biol Med 124:869–874

    PubMed  CAS  Google Scholar 

  • Herrmann K (1953) Über das Vorkommen von o-Phenolase in Labiatenblättern. Pharmazie 8:853–855

    PubMed  CAS  Google Scholar 

  • Herrmann K (1954) Über den Gerbstoff der Melisscnblätter. Arch Pharm 287: 142–147

    Article  CAS  Google Scholar 

  • Hermann K (1956a) Über die Kaffeesäure und Chlorogensäure. Pharmazie 11:433

    Google Scholar 

  • Hermann K (l956b) Über die Gerbstoffe der Lahiatenblätter. Planta Med 4:61

    Google Scholar 

  • Herrmann K (1959) Über das Vorkommen von Gerbstoffen Oxyzimtsäuren und Oxykumarinen in den Blattdrogen des DAB 6. Arch Pharm 292 64:325–329

    Article  PubMed  CAS  Google Scholar 

  • Herrmnnn K (1960) Über den Gerbstoff dcr Labiatenblätter. Arch Pharm 293 12: 1043–1048

    Article  Google Scholar 

  • Hooker JD(ed)(1885) Flora of British India. L Reeve & Co Ltd, The Oast House Brook Ashford Kent 4:651–652

    Google Scholar 

  • Hose S. Zänglein A. Berg Tvd. Schultze W. Kubeczka K-H. Czygan FC (1991) Ontogenetic variation of the essential oil of Melissa officinalis L. Poster presented at the 22nd Symp on Essential oils. St Vincent Aosta. Italy. 11–14 Sept 1991

    Google Scholar 

  • Janistyn H (1974) Taschenbuch der modernen Parfümerie und Kosmetik. 4 Aufl Wiss Verlagsgesellschaft mbH Stuttgart 1974:27

    Google Scholar 

  • Jeremias K (1964) Botan Studien. VEB G Fischer. Jena p 15

    Google Scholar 

  • Kato J, Endo T, Kawamura H, Nakashima Y, Furukoshi K, Oishi K (1990) Inhibition of restriction endonucleases by hot water extracts of spices. Nihon Daigaku Nojuigakubu Gakujutsu Kenkyu Hokoku 47:84–87 cited according to CA 113: 147812b

    Google Scholar 

  • Keng H (1978) Melissa. In Van Steenis-Kruseman MJ (ed): 1-lora Malesiana, serie I, vol 8. Sijthoff & Noordhoff Int Publ, Alphen aan den Rijn, pp 341–342

    Google Scholar 

  • Kireeva SA, Mel’Nikov VN, Reznikova SA, Meshcheryakova NI (1977) Essential oil accumulation in a peppermint callus culture, Fiziol Rast (Moscow) 25:564 570

    Google Scholar 

  • Klosa R (1988) Zur Analytik der flüchtigen Bestandteile verschiedener Pflanzenteile von Melissa officinalis L. Thesis for diploma. Würzburg

    Google Scholar 

  • Koch-Heitzmann I, Schultze W (1984) Melissa officinalis L. Dtsch Apoth Ztg 124:2137–2145

    CAS  Google Scholar 

  • Koch-Heitzmann I. Schultze W (1988) 2000 Jahre Melissa officinalis von der Bienenpflanze zum Virustatikum. Z Phytother 9: 77–85

    Google Scholar 

  • Koch-Heitzmann I, Schultze W (1989a) Fluchtige lnhaltsstoffe in Pflanzlichen Zellkulturen — cine Übersicht (Review). Biochem Physiol Pflanz 184:3–30

    CAS  Google Scholar 

  • Koch-Heitzmann I, Schultze W (I98Yb) Compilation of volatile compounds found in plant cell cultures. In: Schreier P (ed) Bioflavour’ 87 Analysis-biochemistry-biotechnology. W de Gruyter, Berlin, pp 365–395

    Google Scholar 

  • Koch-Heitzmann I, Schultze W, Czygan F-C (1985) Untersuchungen an Kalluskulturen von Melissa officinalis L. II. Über wasserdampfflüchtige Diterpenkohlenwasserstoffe in nicht differenzierten Oberflächcnkulturen. Naturforsch 403: 13–20

    Google Scholar 

  • Koscik A (1955) Antibiotic properties of vegetable oils. Roczniki Akad Med Bialymstoku 1:227 cited according CA 53:11512 (1957)

    Google Scholar 

  • Kuheczka K-H, Schultze W. Ebel S. Weyandt-Spangenberg M (1989) Moglichkeiten und Grenzen der GC-Molekülspektroskopie-Kopplungen, In: Günther W. Matthes JP (eds) In-Com’ 89 Instrumentalized analytical chemistry and computer technology. GIT-Verlag. Darmstadt, pp 131–141

    Google Scholar 

  • Kucera LS. Herrmann EC (1967) Antiviral substances in plants of the mint family (Labiatae). I. Tannin of Melissa officinalis. II. Nontannin polyphenol of Melissa officinalis. Proc Soc Exp Biol Med 124:865–874

    PubMed  CAS  Google Scholar 

  • Kucera LS, Cohen RA, Herrmann EC (1965) Antiviral activities of extracts of the lemon balm plant. Ann NY Acad Sci 13:474–482

    Google Scholar 

  • Lang E. Hörster H (1977) An Zucker gebundene reguläre Monoterpene. Teil II. Untersuchungen zur Ölbildung und Akkumulation ltherischer Öle in Ocimum basilicum Zellkulturen. Planta Med 31:112–118

    Article  PubMed  CAS  Google Scholar 

  • Lange G, Schultze W (1984) The application of high and low resolution mass spectrometry in gc/ms coupling for analyzing complex volatile mixtures of plant tissue cultures. In: Schreier P (ed) Analysis of volatiles. W de Gruyter, Berlin, pp 307–322

    Google Scholar 

  • Lange G. Schultze W (1986) The use of high resolution mass spectrometry in gc/ms coupling for analyzing complex mixtures of volatiles. In: Brunke E-J (ed) Progress in essential oil research. W de Gruyter, Berlin, pp 597–617

    Google Scholar 

  • Leibrand RJ, Duncan WP (1989) Investigation on the chromatographic optimization of combined GC-FTIR-MS. Int LAb 19:46–52

    Google Scholar 

  • Lembke A, Deininger R (1985) Preparation and method for stimulating the immune system. Ger offen DE 3:508 and 875 cited according to CA 104:56451f (1985)

    Google Scholar 

  • Linsmaier EM, Skoog F (1965) Organic growth factor requirements of tobacco tissue cultures. Physiol Plant 18:100–127

    Article  CAS  Google Scholar 

  • Litvinenko VI, Popova TP, Simonjan AV, Zoz IG, Sokolov VS (1975) “Gerbstoffe” und Oxyzimtsäureabkömmlinge in Labiaten. Planta Med 27:372–380

    Article  PubMed  CAS  Google Scholar 

  • Lukic V, Mimika-Dukic N, Gasic O (1989) Contents of essential oil and its components in some Melissa officinalis L. genotypes. Zb Matice Srp Prir Nauke 77:77–82

    CAS  Google Scholar 

  • Masakova NSZ Tserevatüy BS, Trofimenko SL, Remmer GS (1979) The chemical composition of volatile oil in lemon-balm as an indicator of therapeutic use. Planta Med 36:274

    Google Scholar 

  • May G, Willuhn G (1978) Antivirale Wirkung WaBriger Pflanzenextrakte in Gewebekulturen. Arzneim Forsch 28(1): 1–7

    CAS  Google Scholar 

  • Mersinger R, Dornauer H, Reinhard E (1988) Formation of forskolin by suspension cultures of Coleus forskohlii. Planta Med 54:200–204

    Article  PubMed  CAS  Google Scholar 

  • Mill RR (1982) Melissa L. In: Davis PH (ed) The flora of Turkey and the East Aegean Islands, University Press, Edinburgh 7:262–264

    Google Scholar 

  • Miyasaka H, Nasu M, Yamamoto T, Shiomiy, Ohno H, Endo Y, Yoneda K (1987) Effect of nutritional factors on cryptotanshinone and ferruginol production by cell suspension cultures of Salvia miltiorrhiza. Phytochemistry 26:1421–1424

    Article  CAS  Google Scholar 

  • Morelli I (1977) Constituenti e usi della Melissa officinalis. Boll Chim Farm 116:334–340

    PubMed  CAS  Google Scholar 

  • Mose JR, Lukas G (1957) Zur Wirksamkeit einiger ätherischer Öle und deren Inhaltstoffe auf Bakterien. Arzneim Forsch 7:687–692

    CAS  Google Scholar 

  • Mulder-Krieger T, Verporte R, Baerheim-Svendsen A, Scheffer JJC (1988) Production of essential oils and flavours in plant cell and tissue cultures, A review, Plant Cell Tissue Organ Cult 13: 85–154

    Article  CAS  Google Scholar 

  • Mulkens A, Kapetanidis I (1987) Flavonoides des feuilles de Melissa officinalis L. (Lamiaceae). Pharm Acta Helv 62(1): 19–22

    PubMed  CAS  Google Scholar 

  • Mulkens A, Kapetanidis I (1988a) Etude de l’huile essentielle de Melissa officinalis L. (Lamiaceae). Pharm Acta Helv 63(9): 266–270

    CAS  Google Scholar 

  • Mulkens A, Kapetanidis I (1988b) Eugenylglucoside a new natural phenylpropanoid heteroside from Melissa officinalis. J Nat Prod 51:496–498

    Article  PubMed  CAS  Google Scholar 

  • Mulkens A, Stephanou E, Kapetanidis I (1985) Heterosides à genines volatiles dans les feuilles de Melissa officinalis L. (Lamiaceae). Pharm Acta Helv 60(9): 276–278

    CAS  Google Scholar 

  • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue culture. Physiol Plant 15:473–497

    Article  CAS  Google Scholar 

  • Nabeta K, Oda T, Fugimura T, Sugisawa H (1984) Biosynthesis of cuparene from mevalonic acid-6, 6, 6, 2H3 by in vitro callus culture of Perilla sp. Agric Biol Chem 48:1341–1343

    Article  Google Scholar 

  • Nabeta K, Sugisawa H (1982) Terpene biosynthesis by callus of Perilla sp. In: Fujiwara A (ed) Plant tissue culture 1982. Maruzen, Tokyo:289–290

    Google Scholar 

  • Nabeta K, Sugisawa H (1983) Volatile components produced by callus tissues from three Perrilla plants. In: Charalambous G, Inglett G (eds) Instrumental analysis of foods. Recent progress, vol I. Academic Press, New York, pp 65–84

    Chapter  Google Scholar 

  • Nabeta K, Ohnishi Y, Hirose T, Sugisawa H (1983) Monoterpene biosynthesis by callus tissues and suspension cells from Perilla species. Phytochemistry 22:423–425

    Article  CAS  Google Scholar 

  • Nadkarni AK (1976) Indian Materia Medica, vol I, Popular Prakashan, Bombay, p 786

    Google Scholar 

  • Nakanishi T, Miyasaka H, Nasu M, Hashimoto H, Yoneda K (1983) Production of cryptotanshinone and ferruginol in cultured cells of Salvia miltiorrhiza. Phytochemistry 22:721–722

    Article  CAS  Google Scholar 

  • Nykänen I (1985) Progress in flavour research. Composition of the essential oil Melissa officinalis L. In: Adda J, (ed) Flavour research 1984 Elsevier, Amsterdam, pp 329–338

    Google Scholar 

  • Nykänen I, Nykänen L (1986) Flavour composition of lemon balm (Melissa officinalis L.) cultivated in Finland. Lebensm-Wiss Techno1 1986 19:482–485

    Google Scholar 

  • Ozarowski A (1982) Wiad Ziel 4:7

    Google Scholar 

  • Pellecuer J, Enjalbert F, Bessiere JM, Privat G (1981) Contribution à l’etude de l’huile essentielle de melisse: Melissa officinalis L. (Lamiacées). Plant Med Phytother 15(3): 149–153

    CAS  Google Scholar 

  • Petkov VD, Todorov SB, Nikolov N, Zamfirova RN, Krusteva S (1983) On the hypotensive effect of Crataegus monogina, Salvia officinalis, and Melissa officinalis extracts. Doklady Bolgarskoi Akademii Nauk 36(5):689–692

    Google Scholar 

  • Qui SY, Li CK, Zhao DX, Wu CS (1983) Studies of the growth of the callus derived from Thymus quinquecostatus Celak and the formation of its essential oil constituents. Abstr IXth Int Congr Essential oils, 13–17 March 1983, Singapore: 17

    Google Scholar 

  • Reiter M, Brand W (1985) Relaxant effects on tracheal and ileal smooth muscles of the guinea pig. Arzneim-Forsch/Drug Res 35 1:408–414

    CAS  Google Scholar 

  • Sarer E, Kökdil G (1991) Constituents of the essential oil from Melissa officinalis. Planta Med 57:89–90

    Article  PubMed  CAS  Google Scholar 

  • Schenck G, Brieskorn CH (1944) Untersuchungen uber die Inhaltsstoffe der Melisse. Arch Pharm 282:1–9

    Article  CAS  Google Scholar 

  • Schintgen C, Mathis C (1975) Plant Med Phytother 2:107

    Google Scholar 

  • Schultze W, Koch I, Czygan F-C (1983) Untersuchungen an Kalluskulturen von Melissa officinalis L. 1 Mitteilung: Über die Bildung flüchtiger Terpene. Dtsch Apoth Ztg 123:2265–2269

    Google Scholar 

  • Schultze W, Kubeczka K-H, Herres W (1987) Analysis of essential oils by HRGC-FTIR: spectrometric deconvolution of overlapping peaks in balm oil. In: Sandra P (ed) Proc 8th Int Symp Capillary chromatography. Hüthig-Verlag, Heidelberg, pp 657–669

    Google Scholar 

  • Schultze W, Hose S, Schulz J, Hammerschmidt F-J, Zäglein A, Kubeczka K-H (1989a) Investigations of the underground parts of balm (Melissa officinalis L.). Essential oil composition and microscopical studies. Abstr 20th Int Symp on Essential oils, Würzburg, Sept 10–14, 1989:54

    Google Scholar 

  • Schultze W, Klosa R, Zänglein A, Kubeczka KH (1989b) Investigation on the essential leaf oil of balm. Planta Med 55:219–220

    Article  Google Scholar 

  • Schultze W, Zänglein A, Klosa R, Kubeczka KH (1989c) Die Melisse. Dtsch Apoth Ztg 129 4:155–163

    Google Scholar 

  • Schultze W. Koch-Heitzmann I, Hose S, Abou-Mandour A, Zänglein A, Czygan F-C, Kubeczka K-H (1990) Volatiles from callus cultures of Melissa officinalis L. (a) Poster presented at Symp “bonn bacans”, biology and chemistry of active natural substances, Bonn, Germany. (b) Planta Med 56:628

    Article  Google Scholar 

  • Schultze W, Zänglein A, Hose S, Kubeczka K-H, Koch-Heitzmann I, Czygan F-C (1991) Volatiles in flowers of balm (Melissa officinalis L. Lamiaceae). Abstr 1st Symp Advances in Labiate science. Kew, England, April 1991 (Poster 24); Conference volume (in press)

    Google Scholar 

  • Schuster KP (1971) Wirkungsstärke und Wirkungsverluste spamolytisch wirksamer Arzneidrogen, galenischer Zubereitungen und Arzneifertigwaren gepruft am isolierten Darm des Meerschweinchens und am Darm der Katze in situ. Thesis, Munich

    Google Scholar 

  • Flamm S, Kroeber L, Seel H (1940) Pharmakodynamik deutscher Heilpflanzen. Hippokrates Verlag, Stuttgart

    Google Scholar 

  • Skwarek T (1979) Effects of some vegetable preparations on propagation of the influenza viruses in cultures of chicken embryo fibroblasts and chicken embryos. Acta Pol Pharm 5:605–612 cited according to CA 93:37018h

    Google Scholar 

  • Soulimani R, Fleurentin J, Mortier F, Misslin R, Derrieu G, Pelt JM (1991) Neurotropic action of hydroalcoholic extact of Melissa officinalis L. in the mouse. Planta Med 57:105–109

    Article  PubMed  CAS  Google Scholar 

  • Sourgens H, Winterhoff H, Gumbinger HG, Kemper FH (1982) Antihormonal effects of plant extracts: TSH-and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med 45:78–86

    Article  PubMed  CAS  Google Scholar 

  • Spirik G (1991) Natürliche und naturidentische Stoffe für Kosmetische Mittel. Dragoco rep 38(1):24–34

    Google Scholar 

  • Sreenath HL, Jagadishchandra KS (1991) Cymbopogon Spreng (aromatic grasses): in vitro culture regeneration, and the production of essential oils. In: Bajaj YPS (ed) Biotechnology in agriculture and forestry, vol 15. Medicinal and aromatic plants III. Springer Berlin Heidelberg New York, pp 211–236

    Chapter  Google Scholar 

  • Steponaviciene V (1964) Vitamin C content in herbs cultivated in Lithuanian SSR. Lietuvos TSR Aukst Mokyklu Mokslo Darb Med 6:215–218 cited according to CA 65:15990g

    CAS  Google Scholar 

  • Sugisawa H, Ohnishi Y (1976) Isolation and identification of monoterpenes from cultured cells of Perilla plant. Agric Biol Chem 4:231–232

    Article  Google Scholar 

  • Sugisawa H, Chen C, Nabeta K (1984) Simultaneous distillation adsorption and its application. In: Schreier P (ed) Analysis of volatiles. W de Gruyter, Berlin, pp 357–369

    Google Scholar 

  • Sugisawa H, Miwa K, Matsuo T, Tamura H (1988) Volatile compounds produced from the cultured cells of thyme (Thymus vulgaris L.). In: Schreier P (ed) Bioflavour’ 87. W de Gruyter, Berlin, pp 327–340

    Google Scholar 

  • Szöke E, Shavarda AL, Kuzovkina IN (1978) Effect of the culturing conditions of medicinal chamomile flower callus tissue on its essential oil production. Fiziol Rast (Moscow) 25:7431–750 (Translation: ibid 26:579-584)

    Google Scholar 

  • Thieme H, Kitze C (1973) Dber das Vorkommen von Flavonoiden in Melissa officinalis. Pharmazie 28:69–70

    PubMed  CAS  Google Scholar 

  • Tittel G, Wagner H, Bos R (1982) Über die chemische Zusammensetzung von Melissenölen. Planta Med 46:91–98

    Article  PubMed  CAS  Google Scholar 

  • Tubaro E (1965) Qualche considerazione sui farmaci antivirali in studio. Boll Chim Farm 104:272–274

    PubMed  CAS  Google Scholar 

  • Tutin TG et al. (eds) (1972) Flora Europaea. Cambridge University Press, Cambridge, 3:162–163

    Google Scholar 

  • Wagner H, Sprinkmeyer L (1973) Über die pharmakologische Wirkung von Melissengeist. Dtsch Apoth Ztg 113:1159–1166

    CAS  Google Scholar 

  • Watts MJ, Galpin IJ, Collin HA (1984) The effect of growth regulators, light and temperature on flavour production in celery tissue cultures. New Phytol 98: 583–591

    Article  CAS  Google Scholar 

  • Wesley-Hadzija B, Bobing P (1956) Influence of some essential oils on the central nervous system of fish. Ann Pharm Fr 14:283–289

    PubMed  CAS  Google Scholar 

  • Witte L, Berlin J, Wray V, Schubert W, Kohl W, Höfle G, Hammer J (1983) Mono-and diterpenes from cell cultures of Thuja occidentalis. Planta Med 49:216–221

    Article  PubMed  CAS  Google Scholar 

  • Zivanovic LJ, Jovanovic M, Mutavdzic M, Djuric Z, Agatonovic (1990) Densitometric determination of monoterpenoids in Melissa extracts. Fitoterapia 61(1):82–83

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutical Biology, University of Würzburg, Mittlerer Dallenbergweg 64, 97082, Würzburg, Germany

    W. Schultze

  2. Department of Pharmaceutical Biology, University of Hamburg, Bundesstraße 43, 20146, Hamburg 13, Germany

    S. Hose, A. Abou-Mandour & F.-C. Czygan

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  1. W. Schultze
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  2. S. Hose
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  3. A. Abou-Mandour
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  4. F.-C. Czygan
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  1. A-137 New Friends Colony, New Delhi, 110065, India

    Y. P. S. Bajaj

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© 1993 Springer-Verlag Berlin Heidelberg

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Schultze, W., Hose, S., Abou-Mandour, A., Czygan, FC. (1993). Melissa officinalis L. (Lemon Balm): In Vitro Culture and the Production and Analysis of Volatile Compounds. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants V. Biotechnology in Agriculture and Forestry, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58062-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-58062-8_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63459-8

  • Online ISBN: 978-3-642-58062-8

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