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Parameter Sensitivity in a Mathematical Model of Basilar Membrane Mechanics

  • Conference paper
Peripheral Auditory Mechanisms

Part of the book series: Lecture Notes in Biomathematics ((LNBM,volume 64))

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Abstract

A mathematical model of cochlear processing is developed to describe the transformation from acoustic stimulus to intracellular hair cell potential. It incorporates a linear formulation of three-dimensional basilar membrane mechanics, subtectorial fluid-cilia displacement coupling, and a simplified description of the inner hair cell nonlinear transduction process. When the model parameters of the basilar membrane stage are set to values characteristic of the guinea pig, good agreement with experiment is obtained for single tone responses. When the parameters are varied, the basilar membrane tuning can change dramatically.

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References

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Author information

Authors and Affiliations

  1. Mathematical Research Branch, NIADDK, NIH, Bethesda, MD, 20205, USA

    Kathleen A. Morrish & John Rinzel

  2. Biomedical Engineering and Instrumentation Branch, DRS, NIH, Bethesda, MD, 20205, USA

    Richard S. Chadwick

  3. Department of Electrical Engineering, University of Maryland, College Park, MD, 20742, USA

    Shihab A. Shamma

Authors
  1. Kathleen A. Morrish
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  2. Richard S. Chadwick
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  3. Shihab A. Shamma
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  4. John Rinzel
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Editor information

Editors and Affiliations

  1. AT & Bell Laboratories, Murray Hill, NJ, 07974, USA

    J. B. Allen  & J. L. Hall  & 

  2. Department of Otolaryngology and Departments of Systems Computer and Electrical Engineering, Boston University, 110 Cummington Street, Boston, MA, 02215, USA

    A. E. Hubbard

  3. Boys Town National Institute, 555 North 30th Street, Omaha, Nebraska, 68131, USA

    S. T. Neely

  4. Department of Physics, Purdue University, West Lafayette, IN, 47907, USA

    A. Tubis

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© 1986 Springer-Verlag Berlin Heidelberg

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Morrish, K.A., Chadwick, R.S., Shamma, S.A., Rinzel, J. (1986). Parameter Sensitivity in a Mathematical Model of Basilar Membrane Mechanics. In: Allen, J.B., Hall, J.L., Hubbard, A.E., Neely, S.T., Tubis, A. (eds) Peripheral Auditory Mechanisms. Lecture Notes in Biomathematics, vol 64. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50038-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-50038-1_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16095-3

  • Online ISBN: 978-3-642-50038-1

  • eBook Packages: Springer Book Archive

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