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Intracellular Calcium Mediating the Actions of Adenosine at Neuromuscular Junctions

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Topics and Perspectives in Adenosine Research

Summary

This review summarizes the experimental evidence that adenosine derivatives inhibit acetylcho-line release by reducing the intracellular calcium affinity for a strategic component of the secretory apparatus in motor nerve endings. Theoretical curves based upon the calcium receptor model of evoked acetylcholine secretion are provided in support of this notion. The results described also suggest that acetylcholine release need not occur at the active zone to be inhibited by adenosine.

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Authors and Affiliations

  1. Department of Pharmacology, Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, Il, 60611, USA

    E. M. Silinsky, J. K. Hirsh & S. M. Vogel

Authors
  1. E. M. Silinsky
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  2. J. K. Hirsh
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  3. S. M. Vogel
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Editor information

Editors and Affiliations

  1. Physiologisches Institut, Universität München, Pettenkoferstraße 12, 8000, München 2, Federal Republic of Germany

    Eckehart Gerlach  & Bernhard Friedrich Becker  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Silinsky, E.M., Hirsh, J.K., Vogel, S.M. (1987). Intracellular Calcium Mediating the Actions of Adenosine at Neuromuscular Junctions. In: Gerlach, E., Becker, B.F. (eds) Topics and Perspectives in Adenosine Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45619-0_46

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  • DOI: https://doi.org/10.1007/978-3-642-45619-0_46

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45621-3

  • Online ISBN: 978-3-642-45619-0

  • eBook Packages: Springer Book Archive

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