Zusammenfassung
Die Pankreatitis ist eine primär sterile Entzündung des Pankreas, deren Ursprung in einer vorzeitigen intrazellulären Proteaseaktivierung liegt. Eine wichtige Rolle nimmt hierbei die Serinprotease Trypsin ein. Die pathologische intrazelluläre Proteaseaktivierung führt zu einer ausgedehnten Zellschädigung. Ausgelöst durch den lokalen Zellschaden kommt es zu einer systemischen Immunantwort. Die lokale Immunantwort unterstützt den lokalen pankreatischen Schaden und führt zu einer weiter gesteigerten Aktivierung von Proteasen. Auf der anderen Seite kann die systemische Immunantwort zu einem Multiorganversagen, verbunden mit einer erhöhten Mortalität, führen. Sowohl die lokale als auch die systemische Immunantwort definieren letztendlich den Schweregrad der Erkrankung.
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Sendler, M., Mayerle, J., Lerch, M. (2013). Pathogenese und Pathophysiologie der akuten Pankreatitis. In: Beger, H., et al. Erkrankungen des Pankreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37964-2_1
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