Zusammenfassung
Die Bedeutung und Relevanz der Dosis bei der Therapie mit Zytostatika ist allgemein anerkannt [1]. Präklinische Modelle sowohl hämatologischer als auch solider Tumore lassen eine verstärkte Abtötung von Tumorzellen erkennen, wenn maligne Zellpopulationen zytotoxischen Wirkstoffen in höheren Konzentrationen ausgesetzt werden [2].
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Markman, M. (2013). Das Dosis-Wirkung-Prinzip in Verbindung mit der Zufuhr von Antineoplastika. In: Aigner, K.R., Stephens, F.O., Vogl, T.J., Padberg, W. (eds) Regionale Therapie maligner Tumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35014-6_2
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