Abstract
In this paper we present a hybrid 0D-3D modeling method to investigate the hepatic flow in a virtual right lobe hepatectomy (RLH), the surgical procedure for adult-to-adult living donor liver transplanation (LDLT). The 3D method is employed to simulate complex 3D flow in the portal vein, and the 0D model is used to study the systemic hepatic circulation. In particular, we quantify the flow velocity and wall shear stress (WSS) in the left portal vein which increase dramatically post-RLH, and also simulate the essential hepatic distribution features in a healthy adult pre- and post-procedure. We further predict the arterial flow in the remnant left liver, which would decrease due to a hepatic arterial buffer response (HABR) effect. Finally we discuss the physiological significance of these phenomena, and the potential of this hybrid modeling approach.
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© 2012 Springer-Verlag Berlin Heidelberg
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Ho, H., Sorrell, K., Bartlett, A., Hunter, P. (2012). Blood Flow Simulation for the Liver after a Virtual Right Lobe Hepatectomy. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2012. MICCAI 2012. Lecture Notes in Computer Science, vol 7512. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33454-2_65
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DOI: https://doi.org/10.1007/978-3-642-33454-2_65
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-33453-5
Online ISBN: 978-3-642-33454-2
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