Abstract
A cleft of the lip and palate is the result of the failure of lip elements and right and left palatal segments to come together within the first 9 weeks of fetal life. The loss of muscular continuity of the orbicularis oris-buccinator-superior constrictor ring in complete unilateral and bilateral clefts changes the normal muscular force diagram. The aberrant muscular forces act to displace tissue masses. In complete clefts of the lip and palate, if the lateral palatal cleft segments are detached from the vomer, they will be pulled laterally by the external aberrant lip-cheek muscular forces, as well as spread apart by the tongue pushing into the cleft space.
Because clefts differ in their location and extent, lip and palate clefts can vary in the degree of geometric distortion, as well as in the size and shape of the cleft palatal segments. The variety of palatal/lip clefts will be shown and reviewed. The muscular forces that act on the bony scaffolding of the palate and pharynx begin very early in intrauterine life; therefore, the palatal and facial configuration at birth has been formed over the major portion of the infant’s existence prior to birth.
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1 Lip Pits
1.1 Pits of the Lower Lip in Cleft Lip and/or Palate: Genetic Considerations
Pits of the lower lip such as fistulas of lower lip, paramedian sinuses of lower lip, humps of lower lip, or labial cysts are a very rare congenital malformation, first described by Demarquay in 1845 (Demarquay 1845).
This minimally deforming anomaly is remarkable chiefly for its association with facial clefts. The fact that clefts that occur with lip pits seem to run stronger in families than clefts without lip pits has attracted the attention of professionals dealing with cleft patients (Figs. 8.1, 8.2, 8.3, 8.4, and 8.5).
1.2 Frequency
No survey of lip pits has been carried out among the general population; hence, the frequency of this rare anomaly has been only roughly estimated from its incidence in hospital records.
Assuming that 70 (Gorlin and Pindborg 1964) to 80 % (Van der Woude 1954) of patients with pits of the lower lip have associated cleft lip and/or palate and that the frequency of clefts is 1:650 (one in every 650 births), it can be estimated that the frequency of lip pits among the general population is about 1:75,000–1:100,000 (one in every 75,000–100,000 births).
1.3 Morphology
Fistulas of the lower lip usually appear as two pits or humps on the vermilion portion of the lower lip, generally equidistant from the midline. Various kinds of asymmetry may be observed with regard to the midline, or one pit may be positioned more orally. Some pits are mere depressions; others are channels 10–15 mm deep with openings at the top of nipple-like elevations. Some secrete small amounts of viscous saliva but most are asymptomatic.
In exceptional cases, only one pit is present, which may be located either centrally or on one side or the other of the midline of the lower lip. Some cases of single lip pit have occurred in families with members with double lower-lip pits. It can be assumed that a single pit is not a distinct entity but rather an incomplete expression of the trait. On the other hand, the rarely described fistulas of the upper lip (Lannelongue 1879; Radcliff 1940) have not shown any inheritance pattern.
Commissural or angular lip pits – small, usually asymmetrical channels located at the lip angles – are also distinct entities with a much higher incidence and different embryology (Gorlin and Pindborg 1964; Lemke 1959; Everett and Wescott 1961; Witkop 1964; Witkop and Barros 1963; Schuermann et al. 1966).
1.4 Association with Other Malformations
In addition to their strikingly common association with cleft lip and/or palate, pits of the lower lip have been noted in association with other malformations. Gorlin and Pindborg (1964) have found cases of lip pits along with anomalies of extremities, popliteal pterygia, and anomalies of the genitourinary system. The association with cleft lip and/or palate may well form a distinct new syndrome.
A review of the literature suggests that a variety of other anomalies may be associated with lip pits. Among them: syndactyly of the hands together with cleft lip and palate (Lannelongue 1879; Bernauds 1906); mental retardation and cleft, type not specified (Test and Falls 1947); ankyloglossia and cleft lip and palate (Van der Woude 1954); polythelia (Baxter 1939); symblepharon and cleft lip and palate (Oberst 1910); and ankyloblepharon, adhesion between the maxilla and mandible, and cleft uvula (Neuman and Shulman 1961). In two cases of the orofacial digital syndrome, pits were observed by Gorlin and Psaume (1962).
1.5 Inheritance
In most cases of lip pits described during the last 120 years, a marked hereditary pattern was observed. Although all authors have excluded autosomal recessive inheritance or X-linked inheritance, there is no uniform opinion concerning whether or not the condition is due to a single autosomal dominant pleiotropic gene.
Fogh-Andersen (1942, 1961) was the first to clearly point out that the inheritance of clefts in the families with a history of lip pits is of a different character than in families where no lip pits occur. According to Fogh-Andersen (1942, 1961), the role of genetic factors in families with lip pits is much more pronounced, and both genetically different types of clefts (cleft lip or cleft lip and palate and isolated cleft palates) commonly are found within a single family. Fogh-Andersen also stated that in families in which fistulae of lower lip occur as a dominant hereditary character, there are some cases of cleft lip and cleft palate alone. Possibly, it may be explained as the result of coupling of neighboring genes.
Van der Woude (1954), in a careful study of five pedigrees with clefts and lip pits, found that the combination of pits and clefts is based on a single dominant gene of variable expressivity. She agreed with other authors (Test and Falls 1947) that a mildly affected individual can pass the trait on in a very severe form and a severely affected individual can pass the trait on in mild form. The sex of the individual is not a factor in passing on this anomaly. No sex limitation or preference exists.
Patients with clefts but without lip pits (or their parents) often ask for genetic advice. In most of these cases, only a small risk of cleft lip (less than 10 %) is indicated for the next child. But the counseling situation is significantly changed when associated lip pits are found. In this instance, all clefts in the family are considered part of the syndrome, and risk figures for clefts are remarkably higher.
1.6 Evidence of Heterogeneity
It is also clear that the risk of a cleft occurring in a child is significantly higher when the parent has lip pits and a cleft than when the parent has lip pits only. Two alternative explanations for this heterogeneity between families can be considered: (1) The development of clefts in persons carrying a “lip pit” major gene may be influenced by modifying genes at other loci, and (2) in some families, a mutant allele may produce lip pits with only occasional clefts, whereas in other families a different mutant allele (at the same or a different locus) may frequently lead to clefts in addition to lip pits. Thus far, efforts to use the data to support one or the other of these hypotheses have been unsuccessful. Cervenka et al. (1967) reported data from 66 individuals with lip pits in his study and 446 cases with lip pits from the literature with known sex to establishing a 1:1 sex ratio. The frequency of the syndrome was estimated as 1:75,000–1:100,000 in the white population.
Cervenka et al. (1967) further states that family histories can be explained adequately on the basis of autosomal dominant inheritance with variable expressivity of the trait. Penetrance is high, estimated at 80 %. Pits show up more frequently than clefts, and there is a significant association between the types of clefts in parents and their children. Possibly, the development of clefts in this syndrome is influenced by modifying genes or by different mutant alleles with a predilection for the different types of cleft.
2 Orthodontic Treatment, Dentition, and Occlusion
2.1 Crossbite Correction (Figs. 8.6, 8.7, 8.8, 8.9, 8.10, 8.11, and 8.12)
Bergland and Sidhu (1974) advocated postponing orthodontic treatment until complete eruption of the permanent anterior teeth. Segmental alignment can then be corrected with simultaneous manipulation of the anterior teeth. We believe it is best to start maxillary arch expansion when the deciduous dentition is completely erupted and when the children can be easily managed. A three-phase treatment is followed: (1) Buccal crossbite is corrected at 4–6 years, (2) anterior teeth are aligned at 8–9 years, and (3) final orthodontics is utilized at 11-plus years.
Crossbite correction by moving palatal segments laterally in the presence of extensive palatal scarring is difficult and often unsuccessful. Extensive mucoperiosteal undermining, leaving wide denuded palatal bone, was necessary to close the wide palatal cleft at 6 months of age. Uniting the lip moved the palatal segments together (molding action) into good arch approximation. Palatal scar contracture moved the buccal segments farther medially, placing the buccal teeth in crossbite. The anterior dental crossbite does not necessarily reflect diminished anteroposterior maxillary growth but, rather, malposition of the premaxillary teeth of the greater segment.
2.1.1 Unilateral Cleft Lip and Palate
Deciduous and Mixed Dentition: When the smaller segment’s alveolar process is contained within the premaxillary alveolar segment of the larger segment, a dental crossbite occurs between the maxillary and mandibular teeth. Dental dysplasia (eruption of a tooth out of position) may or may not coexist with segmental dislocation. A simple crossbite of one tooth may be due to its malposition rather than to the palatal segment’s collapse. The most frequent crossbite is brought on by the mesioangular rotation of the lesser segment rather than by ectopic tooth eruption. Total buccal crossbite is seen less frequently but is generally present when the palatal tissue is scarred. In either case, the same helix type of palatal expander can be utilized and correction achieved within 2–4 months. Anterior movement of the deciduous central incisors often requires lingual undercuts either by orthodontic bands with lugs or by direct lingual shelf bonding to stabilize the anterior activated palatal finger springs.
A fixed palatal retainer can hold the correction until the second stage of orthodontic therapy is initiated. There is no way to predict the return of a crossbite in the absence of permanent retention. Bone grafting across the alveolar cleft does not guarantee retention of the corrected arch form.
Permanent Dentition: In Class I and Class III cases, it is usually preferable to open the missing lateral incisor space with the expectation of utilizing a fixed bridge to stabilize the corrected arch form and replace the missing tooth. In Class II cases, it may be possible to encourage the cuspid to erupt through the alveolar bone graft in the lateral incisor space, which eliminates the need for extensive orthodontics and bridgework. The cuspid may need to be splinted to the central incisor in order to maintain the corrected arch form.
2.1.2 Bilateral Cleft Lip and Palate
First Stage: Between the ages of 4 and 6 years, the premaxilla is usually ventroflexed and overlaps one or both lateral palatal segments, which may be in partial or complete buccal crossbite. As in unilateral cases, treatment of bilateral cleft lip/palate necessitates moving bony segments into the surrounding muscle ring. If the premaxilla is to be moved forward, bands with lingual lugs are placed on the deciduous central incisors. A fixed helix-type palatal expander with anterior activated finger springs is cemented to the second deciduous molars. The finger springs are positioned under the central incisor-banded lugs for retention. The premaxilla is uprighted prior to correcting the buccal crossbite. The anterior and buccal crossbite correction can be completed within 6 months. As the premaxilla and lateral palatal segments are moved outward, the anterior cleft space is uncovered. A fixed palatal retainer with an acrylic anterior extension to cover the anterior cleft space is placed and kept in position until the alveolar cleft is bone-grafted and all fistulas are surgically closed. Permanent complete palatal retention is necessary, even after alveolar bone grafting. A premaxillary retainer must be placed when the deciduous anterior teeth are lost.
Second Stage: At 7–8 years of age, when the deciduous incisor teeth are replaced by permanent incisors, the anterior crossbite may have to be retreated. The incisors may be rotated and malpositioned. Orthodontic brackets are placed in the upper arch to support a labile arch wire, which will be utilized to reposition the incisor teeth and reduce the premaxillary overbite. A pontic tooth with band is placed on the arch wire to achieve a more pleasing aesthetic result. The premaxilla needs to be properly aligned with the lateral palatal segments prior to alveolar bone grafting; this procedure may be performed between 7 and 9 years of age. A lateral incisor as well as a cuspid may erupt through the area of new bone formation.
Third Stage: Children at 10+ years of age are treated as any other child. The many malocclusion possibilities render it impossible to develop treatment plans for each contingency; instead, basic treatment problems are discussed:
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1.
Class I malocclusion (with anterior and/or buccal crossbite): The crossbite generally is due to lingual bony displacement. The upper arch should be advanced and expanded. If there is sufficient arch length, the missing lateral incisor area is left open. In arch shortage cases, it may be preferable to move the cuspid adjoining the space into the lateral incisor area rather than extract the first bicuspid on that side. A number of variations of treatment exist according to tooth size and location.
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2.
Class II malocclusion: The anterior overjet may be corrected by retraction of the premaxillary central incisors in bilateral cleft lip and/or cleft palate cases. If one or both lateral incisors are missing, it may be best to place the adjoining cuspid in that space and extract either the opposite lateral incisor or the first bicuspid.
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3.
Class III malocclusion: An anterior crossbite does not necessarily signify that a Class III malocclusion exists. In some cases, the anterior teeth can be advanced without excessively increasing their axial inclination. A true depressed midface with poor vertical and anteroposterior development requires midfacial lengthening and advancement. Segmental surgery may have to be utilized to overcome palatal width problems caused by excessive scarring.
2.1.3 Use of Orthopedic Forces to Correct Midfacial Recession
Developing anterior crossbites in either mixed or permanent dentition can be corrected using orthopedic protraction forces. These forces must average 800 g/side and pull downward and forward off hooks placed between the lateral incisor and cuspid. The force needs to be applied 12 h/day. With good cooperation, 5–10 mm of midfacial advancement can be accomplished. The preferred facial mask is the Delaire type.
2.2 Supernumerary (Extra) Teeth, Missing Teeth, and Aplasia (Malformed Teeth)
This occurs more frequently in children with cleft lip and/or palate than in other figuration of the nasal floor (Figs. 8.5, 8.6, 8.13, and 8.14). Bishara and coworkers (1985) studied untreated adults in India who had clefts of the lip and alveolus only, unilateral cleft lip and palate, and bilateral cleft lip and palate. They observed that the maxilla and cranial base were not different from a matched normal population but that the relation of the maxilla and mandible to the cranial base varied according to cleft type. Moss (1969), Moss et al. (1968), Blaine (1969), Dahl (1970), and Krogman et al. (1975) have stated that the cranial base in cleft palate patients differed in both size and shape from noncleft individuals.
The incidence reported in different articles has varied because it is difficult to distinguish between variations rooted in congenital causes and those related to surgery (Bohn 1963). Recently, it has been observed that supernumerary teeth are more common in the deciduous dentition. Moreover, the incidence of supernumerary teeth is greatest in cases of cleft lip only and decreases as the extent of the cleft increases. The relationship is the opposite in cases of aplasia; the incidence of aplasia is lowest for cleft lip only and cleft palate only and increases in proportion to the extent or complexity of the cleft (Brook 1984; Garn et al. 1959, 1960, 1965; Brabant 1967).
In conditions of facial clefting, dental development is, except for the third molars, delayed for all teeth, both maxillary and mandibular (Brook 1984; Garn et al. 1959). Asymmetrical development of tooth pairs, with delayed development on the cleft side, was recorded in approximately half of a group of children with congenital lip and/or palate clefts (Brabant 1967). This supports other observations that eruption is delayed in both dentitions (Garn et al. 1960, 1971, 1977a, b; Ranta 1971, 1972, 1973a, b; Fanning 1961; Dixon 1968; Falkner 1957; Delgado et al. 1975; Demirjian 1986; Fishman 1970; Foster and Lavelle 1971; Galili et al. 1969; Haring 1976; Hatton 1955; Haavikko 1985; Haataja et al. 1972).
Zilberman (1973), from a study on clefts of the lip and alveolar structures, and Mirsa and colleagues (1972), after investigating clefts of the lip and palate, reported that unilateral clefts are more frequent on the left side and are more common in males than in females.
The incidence of dental malocclusion reported in patients with cleft lip and/or palate varied widely in studies by Huddart and Bodenham (1972), Hellquist et al. (1979), Dahl et al. (1981), Norden and associates (1973), Bergland and Sidhu (1974), Nylen and coworkers (1974), Ranta and colleagues (1974a, b), and Hellquist and Skoog (1976). This may be because the patients had varying types of clefts, and their cases were recorded at different ages. Rehrman and coauthors (1973) found the incidence of malocclusion in the mixed dentition to be twice that in the deciduous dentition.
In cases of cleft palate only, Ranta and colleagues (1974a, b) found only a slight increase in anterior crossbite at the transition from the deciduous to the mixed dentition. A noticeable increase in the incidence of anterior crossbite in the mixed dentition, in cases of complete unilateral clefts of the lip and/or palate, was reported by Bergland and Sidhu (1974). This was irrespective of the arch configuration in the deciduous dentition. They also reported that palatal segments stabilized early after lip repair and that further collapse was the exception. However, contrary to the findings just cited, Nylen and coworkers (1974) found no increase in the frequency of anterior crossbite in their mixed-dentition group.
2.3 Caries
Dahl et al. (1989) reported the incidence of caries, gingivitis, and dental abnormalities in preschool children with cleft lip and/or palate in Stockholm, Sweden. Oral health was studied in 49 children 5–6 years old with clefts of the lip and/or palate (CL/P) and 49 healthy children matched for sex and age. The results showed a statistically significant increase in the prevalence and activity of caries among the CL/P children. The average number of decayed and filled tooth surfaces in the cleft group was 7.0 compared with 3.9 in the control group (p < 0.05).
The most evident difference between the two groups was found in the number of decayed proximal surfaces. The mean number of decayed proximal surfaces in the CL/P group was 2.5, compared with 0.9 in the control group (p < 0.001). No significant differences were found in the prevalence and activity of caries among children with isolated clefts of the lip or palate.
The children with cleft lips/palates also exhibited a significant increase (p > 0.01) in the number of gingival units with gingivitis. Other dental abnormalities included increased enamel hypomineralization (p < 0.05), supernumerary teeth (p < 0.001), unilateral crossbite (p < 0.001), and mesial terminal plane (p < 0.01). These results clearly show that children with CL/P as a group must be considered to have an increased risk of caries and gum disease and should therefore have the benefit of additional preventive programs (see Chap. 2).
3 The Relationship Between the Clefting Process and Contiguous Skeletal Structures
Some studies have indicated that clefting is not an isolated defect but may be a syndrome phenomenon with ramifications in contiguous and often remote structures.
In a study of Danish males, Dahl (1970) suggested that the presence of cleft palate, with or without cleft lip, may have ramifications for distant craniofacial structures and their development. Farkas and Lindsay (1972) identified consistent variations in facial morphology in the cleft population and concluded that the cleft defect was not an isolated condition. They reported that what might otherwise be considered the normal side of the face in cases of unilateral clefts was not completely normal and that the anomaly influenced the development of the face equally on both sides.
3.1 The Position of the Cleft Maxilla Within the Cranium and the Mandible
Berkowitz (1985) undertook a mixed cross-sectional study of CUCLP and CBCLP cases to determine whether the maxillary complex relative to the mandible is posteriorly positioned within the face by studying the dental occlusion. None of the cases had presurgical orthopedics, and the hard palate clefts were closed between 18 and 28 months of age using a modified von Langenbeck procedure with a vomer flap. This study was designed to test McNeil’s thesis that the palatal segments, being detached from the nasal septum, are not only reduced in mass but also have not been brought forward with the developing nasal septum. This failure would lead to retrusive midface with a Class III malocclusion.
Berkowitz (1985) found that the occlusal relationships at 6 years of age did show Class I and Class II occlusions, but none of the cases had a Class III occlusion, which would have been present if McNeil’s (McNeil 1950, 1954) hypothesis had been valid. Of the 29 bilateral cases, five cases had a crossbite on one side, one case had a complete bilateral crossbite, and six cases had no crossbites at all. It is quite evident that a buccal crossbite is not, as stated by McNeil, a predictable outcome of the presence of a palatal cleft.
Semb’s (1991a, b) and Ross’s (1987a, b) studies and those already acknowledged elsewhere established that in the cleft population, both the maxilla and mandible are retropositioned within the face (see Chap. 9). However, if McNeil’s beliefs were accurate, the bilateral cleft palatal segments would have been left behind in their growth, and a greater proportion of the cases would have shown a Class III malocclusion on one or both sides.
Chierici and associates (1973) and Bishara and Iversen (1974), Bishara et al. (1985) found a relative retrusion of the maxilla and mandible as well as increased steepness of the mandibular plane in various cleft types. Krogman and his colleagues (1975) reported significant differences in the cleft population in the size of the cranial base, its configuration, and direction of growth. They concluded that the clefting process has growth and/or development implications for the contiguous cranial base and facial structures as well as for the maxilla.
Bishara and Iversen (1974) reported that the posterior positioning of the maxilla and mandible relative to the anterior cranial base may result from the cleft’s influence on contiguous skeletal structures and that clefting affects maxillary development and facial morphology.
3.2 The Cranial Base
Hayashi and colleagues (1976) investigated cranial growth of a large sample of subjects from 4 to 18 years of age with complete unilateral clefts. The investigators found that the cranial base angle was flatter, the maxilla was more retruded, and underdevelopment in both the maxilla and the mandible was more pronounced in girls than in boys. They speculated that upper face height in patients of both genders was less than normal as a result of cleft interference with nasal septal and maxillary suture growth and changes in the configuration of the nasal floor.
3.3 Relationship of the Nasal Cavity to Arch Form (Figs. 8.15 and 8.16)
Aduss and Pruzansky (1967) wrote that the anatomic distortions common to all of their patients with clefts included marked deviation of the nasal septum toward the noncleft side; flattening, particularly of the inferior turbinate on the cleft side; and an anterolateral displacement of the noncleft segment, with an outward and lateral rotation of the premaxillary area adjoining the cleft.
These distortions are the result of unbridled septal growth, deviant maxillary growth, and aberrant vectors of muscle pull. Establishing a continuous muscle band across the cleft, by lip repair, can bring the palatal shelves closer together and modify the configuration of the palatal segments, as well as the configuration of the internal nares.
Peyton and Ritchie (1936), measuring the displacement of the soft tissues of the nose in complete unilateral cleft lip and palate, have shown that deviation of the external part of the nose toward the noncleft side extends for the entire length of the nose, with the greatest displacement at the tip. They further demonstrated that growth of the nasal structures is the same in noncleft children and children with complete unilateral cleft and that the early cleft deformity decreases with time. The natural tendency for self-correction of the septal deviation was evident in the continual uprighting and medial movement of the end of the septum observed in all cases.
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Berkowitz, S., Berkowitz, S., Berkowitz, S. (2013). Lip Pits: Orthodontic Treatment, Dentition, and Occlusion – Associated Skeletal Structures. In: Berkowitz, S. (eds) Cleft Lip and Palate. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30770-6_8
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