Abstract
Salmonella enterica serovar Typhi CT18 (S. Typhi) is the causative agent of typhoid fever in human beings. Currently, most of the drugs used to treat this sickness have adverse side-effects. Moreover, drug-resistant strains are emerging as a serious threat for the disease. Therefore, the most effective drug targets are urgently demanded for the development of new faster-acting antibacterial agents. In this paper, a published method for drug targets identification in Mycobacterium tuberculosis metabolismby Kalapanulak was applied to typhoid fever. The whole genome of S. Typhi was investigated and 282 genes were proposed as new drug targets. Interestingly, 34 drug–affected and essential genes from the three current antibiotics are all found in our proposed drug targets.
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Juntrapirom, A., Kalapanulak, S., Saithong, T. (2010). Genome-Based Screening for Drug Targets Identification: Application to Typhoid Fever. In: Chan, J.H., Ong, YS., Cho, SB. (eds) Computational Systems-Biology and Bioinformatics. CSBio 2010. Communications in Computer and Information Science, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16750-8_19
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DOI: https://doi.org/10.1007/978-3-642-16750-8_19
Publisher Name: Springer, Berlin, Heidelberg
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