Abstract
The signal peptide (SP) is directly associated with a protein’s translocation across biological membranes and consequently with the expression of its functional role. A scheme of predicting the exact position of the SP within a protein is proposed in this work, by applying the continuous wavelet transform (CWT) to the hydrophobic sequence of the protein. The scheme was developed with regard to proteins of known structure extracted from public available databases. The results have verified the effectiveness of the method, which is comparable to existing methods, thus revealing a novel and fast approach to the prediction of SP in single transmembrane proteins, with a prospect of a generalized application.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 International Federation for Medical and Biological Engineering
About this paper
Cite this paper
Avramidou, I.A., Kitsas, I.K., Hadjileontiadis, L.J. (2010). Signal Peptide Prediction in Single Transmembrane Proteins Using the Continuous Wavelet Transform. In: Bamidis, P.D., Pallikarakis, N. (eds) XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010. IFMBE Proceedings, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13039-7_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-13039-7_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13038-0
Online ISBN: 978-3-642-13039-7
eBook Packages: EngineeringEngineering (R0)