Abstract
This chapter summarizes current concepts of dissemination (the processes of leaving the primary lesion and homing to and surviving in a new environment) and metastasis (the successful growth of a cancer cell to a clinically detectable, distant colony) and the role of microenvironmental as well as systemically acting factors in these processes. We review recent research on genotypes and phenotypes of early disseminated cancer cells and discuss the role of tumour dormancy, angiogenesis, and genetic background, aging and the immune system in metastasis.
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Keywords
- Vascular Endothelial Growth Factor
- Cancer Stem Cell
- Circulate Tumour Cell
- Minimal Residual Disease
- Copy Number Change
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Gužvić, M., Klein, C. (2009). The Biology of Cancer Metastasis. In: Molls, M., Vaupel, P., Nieder, C., Anscher, M. (eds) The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74386-6_6
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DOI: https://doi.org/10.1007/978-3-540-74386-6_6
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