Abstract
The importance of the tumor microenvironment for tumor development and progression becomes increasingly evident. A precise and concerted interplay between both the cellular components, i.e., the cells and their mutations, and the acellular components, i.e., the tumor microenvironment, drives tumor growth and spread beyond physiological boundaries as well as promotes cellular resistance to conventional radiotherapy and chemotherapy. One of the prominent microenvironmental modulators of the sensitivity of tumor tissue and tumor-associated normal tissue to therapy is the interaction of cells with the extracellular matrix. Besides serving as structural support for the cells in a tissue, the extracellular matrix participates in the regulation of essential cell functions such as survival, proliferation, differentiation, adhesion, and migration. In this chapter, the overarching function of the tumor-related extracellular matrix is depicted and summarized with regard to the molecular, pathophysiological, and radiobiological aspects associated with tumor biology, radiation, and chemoresistance in the context of cell adhesion molecule families, their interactions with other types of cell surface receptors, and the downstream network of signal transducers.
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Keywords
- Epidermal Growth Factor Receptor
- Focal Adhesion Kinase
- Focal Adhesion
- Neural Cell Adhesion Molecule
- Epidermal Growth Factor Receptor Tyrosine Kinase
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Cordes, N., Hehlgans, S., Eke, I. (2009). Adhesion, Invasion, Integrins, and Beyond. In: Molls, M., Vaupel, P., Nieder, C., Anscher, M. (eds) The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74386-6_5
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