Abstract
The ability to achieve local tumor control and improved overall survival with radiation therapy is limited by the risk of unacceptable normal tissue toxicity. A number of therapeutic interventions targeting the molecular pathways responsible for the development of acute and long-term injury have been investigated in pre-clinical and clinical studies. These interventions have primarily targeted apoptosis, growth factors, and pro-inflammatory and pro-fibrogenic pathways in an attempt to prevent, mitigate, or treat radiation-induced injury. As the mechanisms underlying radiation-induced normal tissue injury are better elucidated, the identification of new potential targets and improved therapeutic interventions will allow patient-stratified dose escalation and improve long-term response rates. The following chapter outlines current target-based interventions being investigated and discusses the recent discovery of novel pathways that may be targeted in the future.
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Keywords
- Radiat Oncol Biol Phys
- Connective Tissue Growth Factor
- Oral Mucositis
- Radiation Therapy Oncology Group
- Radiation Pneumonitis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
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Jackson, I., Anscher, M., Vujaskovic, Z. (2009). Target-Based Interventions to Treat Radiation-Induced Lung Injury. In: Molls, M., Vaupel, P., Nieder, C., Anscher, M. (eds) The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74386-6_12
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