Abstract
Pelvic congestion syndrome is caused by pelvic or vulvar varicosities that may lead to chronic pelvic pain in women. Symptoms are typically described as dull pelvic pain which worsens with prolonged standing. Ovarian vein embolization can provide a minimally invasive means of relieving pain and improving quality of life.
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Keywords
- Pelvic congestion syndrome
- Chronic pelvic pain
- Varicosities
- Ovarian veins
- Venous incompetence
- Transcatheter embolization
- Ovarian vein embolization
Pathophysiology
Chronic pelvic pain – defined as intermittent or constant pain of 3–6 months duration not associated with menses, intercourse, or pregnancy – affects up to 27% of women 18–50 years of age [1, 2]. This pain can cause severe disability with 15% of women missing work and 45% experiencing reduced productivity [3]. There is a vast differential diagnosis for chronic pelvic pain including musculoskeletal, neurologic, gastrointestinal, urinary, gynecologic, and even mental health disorders. Even after diagnostic laparoscopy, nearly 60% of patients remain without a diagnosis for the cause of their pain [4].
Pelvic congestion syndrome (PCS) was first described in 1857 by Richet [5]. In the second half of the twentieth century, a connection was made between pelvic varices and chronic pelvic pain [6]. Pelvic congestion syndrome is caused by pelvic or vulvar varicosities and can be a cause of chronic pelvic pain in 10–30% of women without other obvious pathologies [7, 8]. It tends to be positional; most women describe increasing discomfort with prolonged standing. PCS is caused by incompetence of valves in the gonadal veins or internal iliac veins which leads to pelvic venous insufficiency. Ovarian vein incompetence has been reported in up to 60% of women with PCS [9]. The male analogue is venous incompetence of the gonadal vein leading to varicoceles. Pelvic venous reflux has gained more attention in the past few decades for its potential causal relationship with lower extremity varicose veins. Pelvic venous hypertension is transmitted to the lower extremity venous plexus through the external iliac vein. In one study, pelvic venous reflux was detected in 17% of patients who had recurrence of varicose veins after treatment [10]. In women with pelvic venous insufficiency, 71% demonstrated pelvic venous reflux, and 58% demonstrated communication with the lower extremity superficial veins. Nearly two-thirds of these patients demonstrated recurrence of varicose veins after treatment indicating pelvic venous insufficiency as an important cause of both pelvic congestion syndrome and varicose veins [11].
Key Point
The presence of vulvar varicosities in a patient with lower extremity varicose veins should raise the concern for pelvic congestion syndrome.
Key Point
Risk factors for pelvic congestion syndrome
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Pregnancy
-
Nutcracker syndrome
-
Congenital vascular malformation
-
Genetics
-
Iliac vein compression (May-Thurner syndrome)
-
Hormonal dysfunction
Similar to varicose veins in the legs, the pathophysiology of pelvic venous insufficiency is multifactorial. Pregnancy and genetics play a strong role. During pregnancy, the pelvic and ovarian veins become dilated in response to increased flow of nearly 50% to the fetus and are compressed by the gravid uterus. With multiple pregnancies and repetitive venous dilatation, there may be valve damage which results in reflux. The left ovarian vein and the right internal iliac vein are the most frequently involved [12]. Pelvic congestion syndrome is absent in postmenopausal women likely secondary to the decline of estrogen, which acts as a venous dilator [8].
Occasionally, PCS can be due to upstream occlusion, such as in cases of nutcracker syndrome or iliac vein compression syndrome. Nutcracker syndrome occurs when the left renal vein is compressed between the aorta and SMA resulting in increased pressure and subsequent reflux into the left gonadal vessel (see Chap. 29 for more information). In iliac vein compression syndrome, also known as May-Thurner syndrome, the left common iliac vein is compressed by the right common iliac artery. The left pelvic veins may then develop reflux and flow proceeds through cross-pelvic collaterals to the right internal iliac vein. Rarely, PCS can be secondary to congenital vascular malformations [12].
Clinically, patients are typically multiparous women of childbearing age who present to clinic with pelvic pain. They describe the pain as aching or heaviness in their pelvis worse in the standing position. The pain is exacerbated just before their menstrual period. Commonly they will describe feeling best in the morning, and as they move around, the pain/heaviness will continually increase. Many will describe increasing pain if they are sitting for long periods of time, either at work or on long car or airplane rides. Pain during intercourse is not a common complaint, but they do complain of pain which occurs following intercourse. Postcoital pain is particularly severe if they have intercourse in the morning.
Physical exam may be unrevealing; however a history of unusual varicosities such as gluteal, labial, and/or vulvar varices supports the diagnosis. Lower extremity varicose veins that originate in the upper inner thigh can be supplied by pudendal vein collaterals. Some patients can experience ovarian point tenderness . The combination of a history of postcoital pain and ovarian point tenderness is 94% sensitive and 77% specific for PCS [13].
Clinical Indication
The diagnosis of pelvic congestion syndrome is made through imaging as abnormal physical exam findings or lab values may be absent. Transvaginal ultrasound is typically the first-line imaging. Typically, a patient’s primary gynecologist has already ordered a pelvic sonograph to rule out neoplasm and other ovarian or uterine pathologies. Sonographic diagnostic criteria include tortuous pelvic and ovarian veins which enlarge during Valsalva maneuver. Normal pelvic veins are straight tubular structures with a diameter of less than 4 mm [14]. There may be dilated arcuate veins in the myometrium. Slowed or reversed blood flow and polycystic changes of the ovaries may be identified. Polycystic ovaries are associated with PCS in 56% of cases, although these patients do not typically have hirsutism and amenorrhea [13].
CT and MR diagnostic criteria include the presence of four or more tortuous parauterine veins with diameter of more than 4 mm and ovarian vein diameter greater than 8 mm (Table 13.1, Fig. 13.1) [12]. MR venography has been gaining ground as a diagnostic modality of choice as it demonstrates the venous anatomy while avoiding radiation exposure. MR venography can be used to demonstrate retrograde flow of the ovarian veins [15]. On MR, varices will appear hyperintense on T1-weighted gradient echo sequences. CT and MR may also delineate other etiologies of PCS including compression of the renal or iliac veins as described above. However, both of these cross-sectional imaging techniques are performed with the patient in the supine position, and reflux into the gonadal and pelvic veins is best demonstrated in the standing position. Thus cross-sectional imaging may lead to missed diagnosis in less severe cases.
Key Point
Ovarian varices ≠ PCS, 10% of women with varices are asymptomatic.
The American Venous Forum and Society for Vascular Surgery developed clinical practice guidelines stating that symptomatic patients should undergo noninvasive imaging for evaluation of pelvic venous insufficiency. Ovarian and internal iliac venography should be performed prior to planned intervention and is the gold standard diagnostic test for pelvic congestion syndrome [16]. The first description of venographic visualization of PCS was in 1965 when the tip of the catheter, meant for the left renal vein, happened to lie in the left ovarian vein orifice [17]. In addition to venous diameter, venography can also demonstrate cross-pelvic collaterals on late phase imaging. The procedure is performed through a selected catheterization of the left renal vein with a forceful injection of contrast to evaluate for ovarian venous reflux (Fig. 13.2). Ideally the patient should be studied on a fluoroscopic table which has the capability of being tilted into at least a partial upright position, thus utilizing gravity to help elucidate the patient’s pathology.
Treatment should be based on definitive diagnosis and severity of symptoms. Nearly 10% of asymptomatic women can have ovarian varices , and therefore it is important to exclude other pathologies as the cause of the patients’ pain (Fig. 13.3) [7]. Chronic unremitting undiagnosed pain such as that caused by PCS can often lead to depression. Frequently, these patients can experience incomplete relief of their symptoms if there are several pathologic causes to their pain. When venous incompetence is the sole contributing factor of their symptoms however, patients can do extremely well following treatment.
Key Point
Ovarian and internal iliac venography is the gold standard for PCS diagnosis.
Conventional Therapy
Historically, pelvic congestion syndrome was treated with hysterectomy and commonly oophorectomy. However, there are nonsurgical options which may be tried prior to performing an invasive procedure. The goal of medical therapy is to suppress ovarian function or cause vasoconstriction of the dilated veins. Medroxyprogesterone acetate and the GnRH analogue goserelin have both been used for the treatment of PCS. Both of these drugs demonstrated mild relief of symptoms with short-term results. When combined with psychotherapy, the effects seemed to last longer [18]. This further demonstrates the link between psychological and somatic symptoms of PCS. Side effects of progestins include weight gain and bloating, while side effects of GnRH analogues include depression, night sweats, and vaginal dryness. Given the limited efficaciousness and side effect profile, medical therapy is not indicated for long-term use.
Surgical treatment for PCS directly addressing the gonadal veins was first described in 1984 with extraperitoneal resection of the left gonadal vein which demonstrated improvement or resolution of symptoms of 73% of patients [19]. With advances in technology, laparoscopic transperitoneal ovarian vein ligation became the mainstay therapy in the late 1990s. A study of 23 patients demonstrated complete resolution of patients’ symptoms at 1-year follow-up [20]. Although potentially useful, the procedure is not without its drawbacks. Serious complications include DVT, retroperitoneal hematoma, ileus, and bowel obstruction secondary to adhesions. With the development of interventional transcatheter therapies, this surgical technique has largely been supplanted. In difficult-to-treat patients and patients with recurrent disease, hysterectomy and bilateral oophorectomy are still employed by some gynecologists, but they are less common than previously [21].
Interventional Therapy
Transcatheter embolotherapy of incompetent ovarian veins was first performed in 1993 by Edwards on a single patient who experienced prolonged symptomatic relief of symptoms [22]. Since that time, the technique has become widely available and now is the mainstay for treatment for pelvic congestion syndrome. Numerous studies have demonstrated varying success rates for the reduction of pelvic pain ranging from 47% to 98% [11, 23,24,25]. Of note, patients with isolated ovarian vein reflux had improved outcomes compared to patients with isolated iliac vein reflux or combined disease [11]. No large studies have been performed to date on outcomes of patients with vulvar and lower extremity varicosities after pelvic embolotherapy. Several small studies reported a more than 80% reduction in vulvar varicosities with limited improvement of lower extremity varicosities after treatment [5]. Ovarian vein embolization is a relatively straightforward outpatient procedure.
Key Point
Contraindication to embolization
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Active infection
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Contrast allergy
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Severe coagulopathy
Once a patient has decided to seek treatment for PCS, preoperative imaging with a venous phased MRI or CT (MRV or CTV, respectively) may be performed. This can both determine the extent of varicosities as well as assist with procedural planning. If the patient’s symptoms are very consistent with pelvic congestion syndrome, and she has not had previous cross-sectional images, then some interventional radiologists will proceed directly to venography and embolization. If there is a question as to the diagnosis, then cross-sectional imaging may be helpful, although it is important to recognize that less severe reflux could be missed since the patient will be supine.
Complications of embolotherapy are thankfully rare but do occur. The major complication is migration of coils into the pulmonary arteries, reported in 2% of patients following internal iliac vein embolization [27]. Migration can also occur from coils deployed in the gonadal vein. This risk is increased in vessels >12 mm. Some people advocate for the use of detachable coils to mitigate this risk. Detachable coils are coils that can be deployed but remain attached to the deployment device. If the coil is felt not to be in satisfactory positioning, it can be retracted and redeployed; once it is in appropriate positioning, it can be detached from the deployment device. To prevent coil migration, the diameter of the coil used should be 30–50% larger than the diameter of the internal iliac vein or the gonadal vein [27]. Another complication includes perforation of the ovarian vein; this is not a serious problem since the vein is being embolized and perforation does not cause significant extravasation. Some patients can experience flank pain, thrombophlebitis, postprocedural fevers, and puncture site hematomas also [25]. Recurrence is rare but has been reported in the literature [28]. When nutcracker syndrome is present concurrently, it may be necessary to relieve compression of the left renal vein as well to assure durable relief of PCS symptoms.
Key Point
Complications of ovarian vein embolization
-
Nontarget embolization
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Coil migration
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Vessel perforation
Chronic pelvic pain can be a diagnostic challenge for practitioner and patient alike. In those patients with signs and symptoms of pelvic congestion syndrome, embolization can provide a minimally invasive means of relieving pain and improving quality of life.
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Keefe, N.A., Roberts, A. (2018). Pelvic Congestion Syndrome. In: Keefe, N., Haskal, Z., Park, A., Angle, J. (eds) IR Playbook. Springer, Cham. https://doi.org/10.1007/978-3-319-71300-7_13
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