Abstract
Application of a biodegradable polymer coating is one of the methods to improve the initial corrosion resistance and cytocompatibility of magnesium (Mg) alloys. However, bulging of the coating film during long term immersion has been reported. Therefore, improvement of interface strength between the coating and the substrate surface is a key for the success of this method. Combination of surface modification [silanization with 3-(glycidyloxypropyl) triethoxysilane (GPTES)] and biodegradable polymer coating [poly-L-lactide (PLLA)] were applied to a Mg-2.0Zn-0.98Mn (ZM21) cast alloy.
Results of a cell proliferation assay show that PLLA and GPTES+PLLA coating successfully improved cell growth during 7 days of incubation and suppressed Mg2+ release after 4 days of incubation. The silanization process had no impact on suppression of corrosion. Calcification was observed on all samples after 1 week of incubation with calcification medium, but the calcified area was much larger on the GPTES+PLLA coated sample than on the uncoated sample.
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References
M. Staiger et al., “Magnesium and its alloys as ortopedic biomaterials: a review”, Biomaterials 27 (2006) 1728–1734
M. Maguire and J. Cowan, “Magnesium chemistry and biochemistry”, Biomaterials 15 (2002) 203–210
F. Witte et al., “In vivo corrosion of four magnesium alloys and the associated bone response”, Biomaterials 26 (2005) 3557–3563
L. Xu et al., “In vivo corrosion behavor of Mg-Mn-Zn alloy for bone implant application”, Journal of Biomedical Materials Research Part A 83 (2007) 703–711
G. Song, “Control of biodegradation of biocompatible magnesium alloys”, Corrosion Science 49 (2007) 1696–1701
L. Xu et al., “In vitro corrosion behaviour of Mg alloys in phosphate buffered solution for bone implant application”, Journal of Materials Science: Materials in Medicine, 19 (2008) 1017–1025
Y. Chen et al., “Interaction between a high purity magnesium surface and PCL and PLA coatings during dynamic degradation” Biomedical Materials 6 (2011) 025005
J.E Gray-Munro, C. Seguin and M. Strong, “Influence of surface modification on the in vitro corrosion rate of magnesium alloy AZ91”, Journal of Biomedical Materials Research Part A 91(2009) 221–230
J. Gray and B. Luan, “Protective coatings on magnesium and its alloys- a critical review” Journal of Alloys and Compounds 336 (2002) 88–113
L. Xu and A. Yamamoto, “Characteristics of cytocompatibility of biodegradable polymer film on magnesium by spin coating”, Colloids and Surfaces B: Biointerfaces 93 (2012) 67–74
T. Ishizaki and M. Sakamoto, “Facile formation of biomimetic color-tuned superhydrophobic magnesium alloy with corrosion resistance” Langumir 27 (6) (2011), 2375–2381
Y. Tamada and Y. Ikada, “Cell adhesion to plasma-treated polymer surfaces”, Polymer 34 (10) (1993) 2208 – 2212
M. Burke et al., “Estimation of the strength of adhesion between a thermoresponsive polymer coating and nitinol wire” Journal of Materials Science: Materials in Medicine 19 (2008) 1971–1979
M. Li et al., “Indentation deformation and fracture of thin polystyrene films”, Thin Solid Films 416 (2002) 174–183.
L. Xu and A. Yamamoto, “In vitro degradation of biodegradable polymer-coated magnesium under cell culture conditions”, Applied Surface Science 258 (2012) 6353–6358
A. Witecka, et al., “Surface characterization and cytocompatibility evaluation of silanized magnesium alloy AZ91 for biomedical applications”, Science Technology of Advanced Materials 13 (2012) 064214
J. Gray and B. Luan, “Protective coatings on magnesium and its alloys-a critical review”, Journal of Alloys and Compounds 336 (2002) 88–113.
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© 2014 TMS (The Minerals, Metals & Materials Society)
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Witecka, A., Yamamoto, A., Swieszkowski, W. (2014). Improvement of Cytocompatibility of Magnesium Alloy ZM21 by Surface Modification. In: Alderman, M., Manuel, M.V., Hort, N., Neelameggham, N.R. (eds) Magnesium Technology 2014. Springer, Cham. https://doi.org/10.1007/978-3-319-48231-6_71
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DOI: https://doi.org/10.1007/978-3-319-48231-6_71
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-48589-8
Online ISBN: 978-3-319-48231-6
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