Abstract
The increased temporal and spatial resolution of most modern MDCT scanners enables routine examination of the gastrointestinal tract in small animals. In patients with neoplastic and nonneoplastic obstructive diseases, MDCT can be used to identify the affected segment and, in most cases, the cause of obstruction. In neoplastic conditions, MDCT is essential for staging and aids intervention planning. In fact, the main advantage of MDCT over other imaging techniques and endoscopy is that it enables tumor detection and staging during the same procedure. Advanced MDCT scanners can acquire datasets with the high resolution needed for diagnostic multiplanar reconstruction and 3D virtual endoscopy.
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1 Introduction
The increased temporal and spatial resolution of most modern MDCT scanners enables routine examination of the gastrointestinal tract in small animals. The veterinary literature on this topic is in its infancy, but recent papers have shown the usefulness of contrast-enhanced 16-MDCT as a preliminary screening modality in awake or minimally sedated dogs with acute abdominal signs, including gastrointestinal obstruction and perforation. In patients with neoplastic and nonneoplastic obstructive diseases, MDCT can be used to identify the affected segment and, in most cases, the cause of obstruction. In neoplastic conditions, MDCT is essential for staging and aids intervention planning.
2 MDCT Imaging Strategies
No common strategy for gastrointestinal MDCT has been established for veterinary patients. Patient preparation and scanning protocols can vary, depending on the suspected pathology. At our center, gastrointestinal CT examinations are generally performed with anesthetized patient. This allows performing endoscopy and bioptic procedures under the same anesthesiology episode. In general, adequate distension of the gastrointestinal tract is necessary for the evaluation of wall thickness and integrity, as collapsed intestinal segments can falsely show wall thickening and non-distended gastric plication may conceal small gastric ulcerations. The use of helical hydro-CT for better characterization of gastric tumors has been described in dogs with single-slice CT. The recommended dose of water is 30 mL/kg, and the hydro-CT study should be followed by intravenous contrast medium (CM) administration. The use of air/gas contrast is more appropriate with MDCT scanners than the use of water or other neutral fluids, as it allows the acquisition of endoluminal through-flight images from the same volume dataset. In patients with suspected gastrointestinal hemorrhage (i.e., those with hematemesis), no oral CM should be administered; positive CM may mask bleeding, and water or another neutral CM may dilute the extravasated intravenous CM, thereby compromising the ability to identify the site of bleeding. In post-contrast series, moreover, positive oral CM prevents evaluation of the mucosal pattern of enhancement.
Most advanced MDCT scanners can acquire thin-collimated, near-isotropic, or true-isotropic imaging data for the gastrointestinal tract. Multiplanar and 3D views, including endoluminal imaging, can provide detailed information about various pathological conditions. Acquisition of a pre-contrast series is recommended in patients with suspected gastrointestinal hemorrhage. Post-contrast series should include the (late arterial phase) LAP and (portal venous phase) PVP. Properly timed CM injection can reveal even small lesions and subtle changes in mucosal contrast enhancement. In the LAP (or inflow portal phase), the gastrointestinal mucosa shows maximum enhancement. The arterial phase may show active hemorrhage in patients with benign or malignant gastrointestinal ulceration (Fig. 1). In patients with gastrointestinal tumors, both vascular phases add useful information regarding the vascularity of the mass and the metastasis of lesions to the liver, generally detected in the PVP.
3 Gastrointestinal Thickening
The normal stomach wall thickness is related to the degree of gastric distention, and rugal folds tend to disappear when the stomach is distended. Focal or diffuse gastric wall thickening can be found with inflammatory disease or infiltrative neoplasia, and significant overlap exists between in the imaging features of the two conditions. Gastric wall thickening and thickened folds are common CT sign of gastritis in dogs. Inflammatory polypoid or mass-like folds are difficult to distinguish from gastric lymphoma or other tumors (Figs. 2, 3, 4, and 5).
It has been demonstrated that small intestinal wall thickness varies with weight in the dog, and the duodenal wall is always thicker than the jejunum. In both dogs and cats, the colon wall is generally thinner than the adjacent small intestine, especially when the colon is distended. The gastrointestinal diameter (serosa to serosa) and wall thickness (serosa to mucosa) have been assessed in the non-distended bowels of dogs using single-slice CT. The results (Fig. 6) were similar to those reported for radiology and ultrasound, which remains the first-line imaging modality for the evaluation of diffuse gastrointestinal disease in small animals. Focal or diffuse gastrointestinal thickening is encountered frequently in veterinary patients, has many causes, and is easily documented by MDCT. As has been said for the stomach, many benign and malignant diseases can lead to gastrointestinal thickening , and considerable overlap exists in the appearance of inflammatory and neoplastic diseases (Figs. 7, 8 and 9). The patient’s history and clinical signs are essential in the differential diagnosis. Imaging-guided aspiration, endoscopy, or full thickness biopsies remain necessary for further definition.
4 Gastroduodenal Erosions and Ulcerations
Erosion refers to a defect of the gastric or duodenal mucosa, whereas gastroduodenal ulceration refers to a defect that penetrates the muscularis mucosa. Gastroduodenal ulcerations may develop as the consequence of excessive acid, pepsin, or other harmful substance; they can occur independently or as a complication of many systemic diseases and medical treatments. Inflammatory conditions (gastroenteritis) and the use of steroids and nonsteroidal anti-inflammatory drugs are probably the most common causes of gastrointestinal erosion and ulceration in veterinary patients. Anti-inflammatory drugs decrease local prostaglandin production, thereby reducing mucosal blood flow and limiting the epithelium’s capacity to protect itself from the injurious effects of gastric acid. Many other diseases (e.g., mast cell tumor, gastrinoma) are associated with increases in histamine and gastrin levels, which increase gastric acid production, leading to gastrointestinal erosion and ulceration.
MDCT of erosion and gastroduodenal ulceration in small animals has not been described to date. Many MDCT characteristics of gastroduodenal ulceration reported in humans may be observed also in dogs and cats with this condition, with the appropriate use of advanced MDCT technology. Direct and indirect MDCT signs may be encountered in veterinary patients. The disruption of mucosal enhancement (in the LAP) and focal luminal outpouching (ulcer crater development) are the most common direct CT signs of ulceration associated with benign and malignant conditions (Figs. 10, 11, 12, and 13). Indirect signs of erosion or gastric ulceration include gastric fold thickening , mucosal hyperenhancement, and perigastric/periduodenal inflammation (e.g., increased opacity of fat with hazy/ground-glass-like appearance, presence of fluid film). In complicated cases, other CT signs may be present. Complications of gastroduodenal ulceration include active hemorrhage and perforation. Active hemorrhage may not be noted unless a tailored protocol is performed. Direct scans may or may not reveal hyperattenuating material, especially in cases of intermittent bleeding. In the detection of active bleeding with CTA, the greatest sensitivity is achieved by combining findings from the arterial phase and PVP. CM extravasation is observed during the arterial phase, and CM pooling/accumulation is visible during the PVP (Fig. 14). Pre-contrast and dual-phase MDCT of the abdomen should always be performed in patients with histories of hematemesis or hematochezia or laboratory signs of gastrointestinal bleeding.
5 Gastrointestinal Perforation
Gastrointestinal perforation can have various causes in veterinary patients. Most perforations are emergency conditions of the abdomen that require early recognition and timely surgical treatment. Gastrointestinal ulcers, necrotic or ulcerated malignancies, and iatrogenic and traumatic injuries are the most common causes of GIP. MDCT is very sensitive in GIP detection, and it can also be used to localize the perforation site. In humans, the reported overall accuracy of CT for bowel perforation site prediction ranges from 82 to 90%. The diagnosis of GIP is based on direct and indirect MDCT findings. Direct CT signs are discontinuity of the bowel wall and the presence of extraluminal air. Indirect MDCT findings of GIP include intestinal wall thickening, abnormal wall enhancement, abscess, and the presence of an inflammatory peritoneal mass adjacent to the perforated intestinal segment (Figs. 15 and 16). Depending on the perforation site, free air may be detected in intraperitoneal or retroperitoneal spaces. Gastric and small bowel perforation leads to pneumoperitoneum, whereas large bowel perforation may lead to pneumoretroperitoneum (Fig. 15c). In small bowel perforations, especially when the amount of air is small, concentrated free air bubbles may be seen in close proximity to the intestinal wall. In these cases, MDCT images should be examined thoroughly because free air bubbles tend to stay near the wall from which they arise, and their location may thus aid determination of the perforation site.
6 Gastrointestinal Obstruction
Gastric outlet obstruction may occur in association with congenital and acquired conditions. Pyloric stenosis refers to congenital benign muscular hypertrophy of the pylorus and is seen in young brachycephalic dogs and Siamese cat. Acquired conditions (e.g., foreign bodies, masses, or infiltrative diseases) can cause hypertrophy of the antral mucosa or a combination of both muscular and mucosal thickening (e.g., chronic hypertrophic pyloric gastropathy) (Figs. 17 and 18). Other nonneoplastic conditions leading to gastric outlet obstruction include intussusception and herniation (hernias are treated in the Chapter “The Peritoneal Cavity, Retroperitoneum, and Abdominal Wall”). Intussusception involving the stomach is rarely reported in dogs and cats. A few cases of pylorogastric intussusception have been reported in the veterinary literature to date. Gastro-gastric intussusception not involving the pylorus is also possible (Fig. 19).
Many intrinsic and extrinsic conditions may lead to intestinal narrowing. Common causes of mechanical small and large bowel obstruction in dogs and cats are foreign bodies, intussusception, inflammation, neoplasia, abscess, granuloma, and strictures. MDCT examination is generally required in patients with suspected malignant gastrointestinal obstruction or in those with clinical signs of obstruction and unclear results of first-level imaging. In humans, CT evaluation of mechanical intestinal obstruction is highly sensitive, specific, and accurate, allowing identification of the site and cause of obstruction with up to 100% sensitivity. In a recent study, CT outperformed digital radiology in the determination of site and cause of obstruction in 20 dogs, showing greater sensitivity (95.8 vs. 79.2%) and specificity (80.6 vs. 69.4%).
Most CT signs of obstruction reported in humans are encountered also in veterinary patients. Direct CT signs of mechanical intestinal obstruction or strangulation include dilated fluid-filled bowel loops with normal or collapsed distal loops; bowel thickening (mural edema or hemorrhage); U- or C-shaped appearance in cases of volvulus; and hyperattenuation of an intestinal segment on pre-contrast images with absent, reduced, or delayed intestinal wall enhancement on post-contrast images (bowel ischemia or hypoperfusion) (Figs. 20, 21, 22, 23, 24, and 25). Indirect signs include stretched or prominent mesenteric vessels, the “whirl sign ” for twisted mesenteric vessels (also seen in torsion of other abdominal organs), and mesenteric fat stranding (Fig. 26). The latter has been described as a feature of mechanical obstruction in dogs, but it is not specific to obstruction and can be found in a broad spectrum of abdominal diseases. However, when detected in patients with suspected gastrointestinal obstruction, it should prompt the examiner to evaluate the regional viscera more rigorously, as it frequently appears adjacent to the obstructed intestinal segment. Other CT signs, such as mesenteric thrombosis and the reticulonodular mesenteric pattern, seen in neoplastic conditions, may accompany mechanical bowel obstruction. Advanced small bowel obstruction leads to bowel dilatation and necrosis or perforation of the intestinal wall (Fig. 16).
Intestinal pseudo-obstruction is a functional disorder of the bowel mimicking clinical and imaging signs of obstruction but in the absence of any mechanical obstruction. The differentiation between true bowel obstruction and pseudo-obstruction may be problematic using only first-line imaging modalities. MDCT may play an important role in the diagnostic workup of pseudo-obstruction, as it can rule out mechanical causes of obstruction (Fig. 27). However, full thickness intestinal biopsies are the only diagnostic procedure that allows the definitive diagnosis.
7 Gastrointestinal Masses
Primary gastric and small bowel tumors are rare in small animals. Canine gastric cancer is diagnosed rarely and is reported to account for approximately 0.1–0.5% of canine neoplasias. MDCT characteristics of various tumor types have not been reported in the veterinary literature, and the definitive diagnosis of gastrointestinal tumors is based on cytological or histological demonstration of neoplastic cells.
The main advantage of MDCT over other imaging techniques and endoscopy is that it enables tumor detection and staging during the same procedure. Advanced MDCT scanners can acquire datasets with near-isotropic voxels, with the high resolution needed for diagnostic multiplanar reconstruction and 3D endoluminal imaging. Dorsal, sagittal, and multioblique views of small bowel tumors demonstrate signs of small bowel obstruction, perforation, as well as the mural and extramural extent of small bowel malignancies. Such visualization aids the planning of further diagnostic steps and surgical resection. In addition, regional extent and metastases or peritoneal seeding can be detected with whole-body MDCT .
Benign gastrointestinal tumors (leiomyoma, adenoma) are often discovered incidentally in middle-aged or older patients. Benign gastric tumors may be located submucosally, intramurally, or subserosally and appear on CT as nodular eccentric mural thickening, generally well circumscribed, covered by intact mucosa, with a homogenous appearance and uniform contrast enhancement (Fig. 28). Carcinomas (adenocarcinoma and other subtypes) are the most common gastric tumors in dogs, accounting for 50–90% of cases, followed by leiomyosarcomas and lymphoma (Figs. 1, 5, 13, 17c, 18, and 29). The Tervuren, Bouvier des Flandres, Groenendael, Collie, standard Poodle, and Norwegian Elkhound breeds have been found to have a significantly increased risk of gastric carcinoma. Lymphosarcoma (isolated or as part of a more diffuse gastrointestinal tumor) is the most commonly reported primary gastric tumor in cats. It has a diverse array of appearances, ranging from infiltrative to polypoid lesions. Gastric adenocarcinomas are rare in cats. Extramedullary plasmacytomas have been described as primary gastric or bowel tumors in dogs and cats. Primary histiocytic sarcoma of the stomach has also been documented in dogs.
Adenocarcinoma and lymphosarcoma are the most common intestinal tumors in dogs and cats. Other bowel tumor types include leiomyomas, leiomyosarcomas, gastrointestinal stromal tumors, plasma cell tumors, mast cell tumors, carcinoids (tumors of neuroendocrine origin), and extraskeletal osteosarcomas (Figs. 8b, c, 9, 20c, 30, 31, and 32). Active gastrointestinal hemorrhage can accompany gastrointestinal cancer with mucosal ulceration, as well as benign ulcers (Fig. 1). Benign polyps and adenomas can be found in the feline duodenum and canine rectum. The absence of mesenteric change and metastasis aids the diagnosis and rules out most malignancies. Malignant tumors of the rectum may show local infiltration, and the definition of the tumoral boundaries based on MDCT images only may be difficult (Figs. 14, 25, 33, 34).
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Bertolini, G. (2017). The Gastrointestinal System. In: Bertolini, G. (eds) Body MDCT in Small Animals. Springer, Cham. https://doi.org/10.1007/978-3-319-46904-1_7
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