Abstract
Free radical scavengers have been shown to improve short-term outcome after intracerebral hemorrhage (ICH). The purpose of this study was to evaluate whether melatonin (a potent free radical scavenger and an indirect antioxidant) can improve short- and=or long-term neurological function after ICH, which was induced by collagenase injection into the striatum of adult rats. Melatonin (15mg/kg) was administered by intra-peritoneal injection at 1, 24, 48, and 72h. Neurological and behavioral testing was performed at several time points from 1 day to 8 weeks post-ICH. Neurological and behavioral deficits were observed in ICH rats at all time points, but the melatonin treatment regimen did not improve performance or level of brain injury.
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Hartman, R.E. et al. (2008). Long-term effects of melatonin after intracerebral hemorrhage in rats. In: Zhou, LF., et al. Cerebral Hemorrhage. Acta Neurochirurgica Supplementum, vol 105. Springer, Vienna. https://doi.org/10.1007/978-3-211-09469-3_20
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DOI: https://doi.org/10.1007/978-3-211-09469-3_20
Publisher Name: Springer, Vienna
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