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Effects of drugs on calmodulin-mediated enzymatic actions

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 33))

Abstract

The Ca2+-dependent regulatory protein, CaM, has been shown to be involved in the regulation of numerous Ca2+-mediated events [1–7]. This ubiquitous protein appears to be primarily located in the soluble fraction of those cells in which its subcellular distribution has been examined [8]. However, it is partly also an integral component of supramolecular structures in the highly organized interior of the cell.

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Abbreviations

CaM:

calmodulin

PDE:

cyclic nucleotide phosphodiesterase [EC 3.1.4.17]

MLCK:

myosin light chain kinase [EC 3.6.1.3]

PKF:

phosphofructokinase [EC 2.7.1.11]

GAPD:

glyceraldehyde-3-phosphate dehydrogenase [EC 1.2.1.12]

ELISA:

enzyme-linked immunosorbent assay

EGTA:

ethylene glycol bis(β-aminoethylether)-N, N′ tetraacetic acid

TFP:

trifluoperazine

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  1. Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, P. O. B. 7, H-1502, Budapest, Hungary

    Judit Ovádi

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  1. Judit Ovádi
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  1. Basel, Switzerland

    Ernst Jucker

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© 1989 Birkhäuser Verlag Basel

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Ovádi, J. (1989). Effects of drugs on calmodulin-mediated enzymatic actions. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 33. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9146-2_11

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  • DOI: https://doi.org/10.1007/978-3-0348-9146-2_11

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9925-3

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