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Summary

This essay discusses new evidence supporting the concept that the distinct sensibilities for pain and temperature are based in part on specific ‘labeled lines’ that interact centrally as components of an ascending projection system subserving homeostasis and the generalized sense of the condition of the body itself (common sensation, or “Gemeingefühl”).

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References

  • Allen, G.V., Saper, C.B., Hurley, K.M. and Cechetto, D.F. (1991) Organization of visceral and limbic connections in the insular cortex of the rat. Journal of Comparative Neurology311:1–16.

    Article  PubMed  CAS  Google Scholar 

  • Apkarian, A.V., Stea, R.A. and Bolanowski, S.J. (1994) Heat-induced pain diminishes vibrotactile perception: A touch gate. Somatosensory and Motor Research11:259–267.

    Article  PubMed  CAS  Google Scholar 

  • Berthier, M.L., Starkstein, S.E. and Leiguarda, R.C. (1988) Asymbolia for pain:a sensory-limbic disconnection syndrome. Annals of Neurology24:41–49.

    Article  PubMed  CAS  Google Scholar 

  • Biemond, A. (1956) The conduction of pain above the level of the thalamus opticus. Arch. Neurol. Psychiat.75:231–244.

    CAS  Google Scholar 

  • Boivie, J., Leijon, G. and Johansson, I. (1989) Central post-stroke pain—A study of the mechanisms through analyses of the sensory abnormalities. Pain37:173–185.

    Article  PubMed  CAS  Google Scholar 

  • Boring, E.G. (1942) Sensation and Perception in the History of Experimental Psychology. Appleton-Century-Crofts, New York.

    Google Scholar 

  • Bushnell, M.C., Craig, A.D., Reimann, E.M., Yun, L.-S. and Evans, A. (1995) Cerebral activation in the human brain by pain, temperature and an illusion of pain. Society for Neuroscience Abstracts21:1637.

    Google Scholar 

  • Christensen, B.N. and Perl, E.R. (1970) Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn. Journal of Neurophysiology33:293–307.

    PubMed  CAS  Google Scholar 

  • Coghill, R.C., Talbot, J.D., Evans, A.C, et al. (1994) Distributed processing of pain and vibration by the human brain. Journal of Neuroscience14:4095–4108.

    PubMed  CAS  Google Scholar 

  • Craig, A.D. (1991) Spinal distribution of ascending lamina I axons anterogradely labeled with Phaseolus vulgarisleucoagglutinin (PHA-L) in the cat. Journal of Comparative Neurology313:377–393.

    Article  PubMed  CAS  Google Scholar 

  • Craig, A. D. (1993) Propriospinal input to thoracolumbar sympathetic nuclei from cervical and lumbar lamina I neurons in the cat and the monkey. Journal of Comparative Neurology331:517–530.

    Article  PubMed  CAS  Google Scholar 

  • Craig, A. D. (1995) Distribution of brainstem projections from spinal lamina I neurons in the cat and the monkey. Journal of Comparative Neurology (in press).

    Google Scholar 

  • Craig, A. D. (1996) Supraspinal projections of lamina I neurons. In: J.-M. Besson(ed.): Forebrain Processing of Pain, John Libbey, Paris, (in press).

    Google Scholar 

  • Craig, A. D. and Bushnell, M.C. (1994) The thermal grill illusion: unmasking the burn of cold pain. Science265:252–255.

    Article  PubMed  CAS  Google Scholar 

  • Craig, A.D., Bushnell, M.C, Zhang, E.-T. and Blomqvist, A. (1994) A thalamic nucleus specific for pain and temperature sensation. Nature372:770–773.

    Article  PubMed  CAS  Google Scholar 

  • Craig, A.D. and Hunsley, S.J. (1991) Morphine enhances the activity of thermoreceptive cold-specific lamina I spinothalamic neurons in the cat. Brain Research558:93–97.

    Article  PubMed  CAS  Google Scholar 

  • Craig, A.D. and Serrano, L.P. (1994) Effects of systemic morphine on lamina I spinothalamic tract neurons in the cat. Brain Research636:233–244.

    Article  PubMed  CAS  Google Scholar 

  • Craig, A.D. and Kniffki, K.-D. (1985) Spinothalamic lumbosacral lamina I cells responsive to skin and muscle stimulation in the cat. Journal of Physiology (Lond)365:197–221.

    CAS  Google Scholar 

  • Damasio, A.R. (1993) Descartes’ Error: Emotion, Reason, and the Human Brain. Putnam, New York.

    Google Scholar 

  • Derbyshire, S.W.G., Jones, A.K.P., Devani, P., Fristen, K.J., Feinmann, C., Harris, M., and Frackowiak, R. (1994) Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography. Journal of Neurology, Neurosurgery, and Psychiatry57:1166–1172.

    Article  PubMed  CAS  Google Scholar 

  • Dostrovsky, J.O. and Craig, A.D. (1993) Antidromic identification of nociceptive lamina I cell terminations in the cat thalamus. Society for Neuroscience Abstracts19:1572.

    Google Scholar 

  • Dostrovsky, J.O. and Hellon, R. F. (1978) The representation of facial temperature in the caudal trigeminal nucleus of the cat. Journal of Physiology (Lond) 211:29–47.

    Google Scholar 

  • Dostrovsky, J.O., Shah, Y. and Gray, B.G. (1983) Descending inhibitory influences from periaqueductal gray, nucleus raphe magnus, and adjacent reticular formation: II. Effects on medullary dorsal horn nociceptive and nonnociceptive neurons. Journal of Neurophysiology49:948–960.

    PubMed  CAS  Google Scholar 

  • Dostrovsky, J.O., Wells, F.E.B. and Tasker, R.R. (1992) Pain sensations evoked by stimulation in human thalamus. In: R. Inoka, Y. Shigenaga and M. Tohyama (eds.): Processing and Inhibition of Nociceptive Information, International Congress Series 989, Excerpta Medica, Amsterdam, pp 115–120.

    Google Scholar 

  • Ferrington, D.G., Sorkin, L.S. and Willis, W.D. (1987) Responses of spinothalamic tract cells in the superficial dorsal horn of the primate lumbar spinal cord. Journal of Physiology (Lond)388:681–703.

    CAS  Google Scholar 

  • Fruhstorfer, H. and Lindblom, V. (1983) Vascular participation in deep cold pain. Pain17:235–242.

    Article  PubMed  CAS  Google Scholar 

  • Georgopoulos, A.P. (1976) Functional properties of primary affernt units probably related to pain mechanisms in primate glabrous skin. Journal of Neurophysiology39:71–83.

    PubMed  CAS  Google Scholar 

  • Han, Z.-S. and Craig, A.D. (1994) Morphological characteristics of physiologically identified lamina I cells in cats. Society for Neuroscience Abstracts20:547.

    Google Scholar 

  • Hassenbusch, S.J., Pillay, P.K. and Barnett, G.H. (1990) Radiofrequency cingulotomy for intractable cancer pain using stereotaxis guided by magnetic resonance imaging. Neurosurgery27: 220–223. Hassler, R. and Riechert, T. (1959) Klinische und anatomische Befunde bei stereotaktischen Schmerzoperationen im thalamus. Archives in Psychiatry200:93–122.

    Google Scholar 

  • Head, H. and Holmes, G. (1911) Sensory disturbances from cerebral lesions. Brain34:102–254.

    Article  Google Scholar 

  • Heppelmann, B., Messlinger, K., Neiss, W.F. and Schmidt, R.F. (1995) Fine sensory innervation of the knee joint capsule by group III and group IV nerve fibers in the cat. Journal of Comparative Neurology351:415–428.

    Article  PubMed  CAS  Google Scholar 

  • Hsieh, J.-C, Hägermark, S., Ståhle-Bäckdahl, M., Ericson, K., Ericksson, L., Stone-Elander, S., and Ingvar, M. (1994) Urge to scratch represented in the human cerebral cortex during itch. Journal of Neurophysiology72:3004–3008.

    PubMed  CAS  Google Scholar 

  • Jeanmonod, D., Magnin, M. and Morel, A. (1993) Thalamus and neurogenic pain: physiological, anatomical and clinical data. NeuroReport4:475 –478.

    Article  PubMed  CAS  Google Scholar 

  • Klement, W. and Arndt, J.O. (1992) The role of nociceptors of cutaneous veins in the mediation of cold pain in man. Journal of Physiology (Lond.)449:73–83.

    CAS  Google Scholar 

  • Kumazawa, T., Perl, E.R., Burgess, P.R. and Whitehorn, D. (1975) Ascending projections from marginal zone (lamina I) neurons of the spinal dorsal horn. Journal of Comparative Neurology162:1–12.

    Article  Google Scholar 

  • LaMotte, R.H. and Thalhammer, J.G. (1982) Response properties of high-threshold cutaneous cold receptors in the primate. Brain Research244:279–287.

    Article  PubMed  CAS  Google Scholar 

  • Lenz, F.A., Seike, M., Richardson, R.T., Lin, Y.C., Baker, F.H., Khoja, I., Jaeger, C.J., and Gracely, R.H. (1993) Thermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus. Journal of Neurophysiology70:200–212.

    PubMed  CAS  Google Scholar 

  • Maclver, M.B. and Tanelian, D.L. (1992) Activation of C fibers by metabolic perturbations associated with tourniquet ischemia. Anesthesiology76:617–623.

    Article  Google Scholar 

  • Moskowitz, M.A. (1991) The visceral organ brain: implications for the pathphysiology of vascular head pain. Neurology41:182–186.

    PubMed  CAS  Google Scholar 

  • Perl, E.R. (1984b) Why are selectively responsive and multireceptive neurons both present in somatosensory pathways? In: C. v. Euler, O. Franzen, U. Lindblom, and D. Ottoson (eds.): Somatosensory Mechanisms, MacMillan Press, London, pp 141–161.

    Google Scholar 

  • Pickar, J.G., Hill, J. M. and Kaufman, M. P. (1994) Dynamic exercise stimulates group III muscle afferents. Journal of Neurophysiology71:753–760.

    PubMed  CAS  Google Scholar 

  • Poulos, D.A. and Benjamin, R.M. (1968) Response of thalamic neurons to thermal stimulation of the tongue. Journal of Neurophysiology31:28–43.

    PubMed  CAS  Google Scholar 

  • Price, D.D., Hayes, R.L., Ruda, M. and Dubner, R. (1978) Spatial and temporal transformations of input to spinothalamic tract neurons and their relation to somatic sensations. Journal of Neurophysiology41:933–947.

    PubMed  CAS  Google Scholar 

  • Richardson, D.E. (1967) Thalamotomy for intractable pain. Confinia neurologica 29:139–145.

    Article  PubMed  CAS  Google Scholar 

  • Schouenborg, J. and Sjölund, B.H. (1983) Activity evoked by A- and C-afferent fibers in rat dorsal horn neurons and its relation to a flexion reflex. Journal of Neurophysiology 50:1108–1121.

    PubMed  CAS  Google Scholar 

  • Sherrington, C.S. (1900) Cutaneous sensations. In: E.A. Schäfer (ed.): Text-book of Physiology, Pentland, Edinburgh, pp 920–1001.

    Google Scholar 

  • Sikes, R.W. and Vogt, B.A. (1992) Nociceptive neurons in area 24 of rabbit cingulate cortex. Journal of Neurophysiology68:1720–1732.

    PubMed  CAS  Google Scholar 

  • Steen, K.H., Steen, A.E. and Reeh, P.W. (1995) A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro. Journal of Neuroscience15: 3982–3989. Strassman, A. M., Mineta, Y. and Vos, B. P. (1994) Distribution of fos-like immunoreactivity in the medullary and upper cervical dorsal horn produced by stimulation of dural blood vessels in the rat. Journal of Neuroscience14:3725–3735.

    Google Scholar 

  • Strassman, A.M. and Vos, B.P. (1993) Somatotopic and laminar organization of fos-like immunoreactivity in the medullary and upper cervical dorsal horn induced by noxious facial stimulation in the rat. Journal of Comparative Neurology331:495–516.

    Article  PubMed  CAS  Google Scholar 

  • Sugiura, Y., Lee, C.L. and Perl, E.R. (1986) Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science234:358–361.

    Article  PubMed  CAS  Google Scholar 

  • Thunberg, T . (1896) Förnimmelserne vid till samma ställe lokaliserad, samtidigt pågående köld- och värmeretning. Uppsala Läkareförenings Förhandlingar, Första bandet, P. Hedenius and JA. Hammar(eds.), Akademiska boktryckeriet, pp. 489–495.

    Google Scholar 

  • Wahren, L.K., Torebjörk, E. and Jörum, E. (1989) Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain38:313–319.

    Article  PubMed  CAS  Google Scholar 

  • Weber, E.H. (1846) Der Tastsinn und das Gemeingefühl. In: R. Wagner (ed.): Handwörterbuch des Physiologie mit Rücksicht auf physiologische Pathologie, Bd 3, Abt2, Biewig und Sohn, Braunschweig, pp 481–588.

    Google Scholar 

  • Yarnitsky, D. and Ochoa, J.L. (1990) Release of cold-induced burning pain by block of cold-specific afferent input. Brain113:893–902.

    Article  PubMed  Google Scholar 

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Craig, A.D.B. (1996). Pain, temperature, and the sense of the body. In: Franzén, O., Johansson, R., Terenius, L. (eds) Somesthesis and the Neurobiology of the Somatosensory Cortex. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9016-8_3

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  • DOI: https://doi.org/10.1007/978-3-0348-9016-8_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9868-3

  • Online ISBN: 978-3-0348-9016-8

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