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Bronchoalveolar lavage

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Methods in Pulmonary Research

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Abstract

Bronchoalveolar lavage (BAL) is a method that allows the recovery of both cellular and noncellular components from the epithelial fluid lining the respiratory tract and differs from bronchial washings, which refer to the aspiration of either secretions or small amounts of instilled saline from large airways. BAL is accomplished by infusing a physiological salt solution through the bronchoscope and then recovering the infused solution together with the epithelial lining fluid (ELF) [1, 2]. Diagnostic BAL has to be differentiated from therapeutic BAL with the need of larger volumes (up to 10 to 20 1), performed through a double lumen tube that selectively catheterizes a major bronchus. The latter procedures are used periodically in patients with alveolar proteinosis and occasionally in subjects with cystic fibrosis or in those with special inhaled particles or noxious gas exposure, however, the indications for massive, whole lung lavage under general anaesthesia are few [2]. Generally, BAL is done in conjunction with fiberoptic bronchoscopy.

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References

  1. Crystal RG, Reynolds HY and Kalica AR (1986) Chest 90: 122

    Article  PubMed  CAS  Google Scholar 

  2. Reynolds HY (1987) Am. Rev. Respir. Dis. 135: 250

    PubMed  CAS  Google Scholar 

  3. Klech H and Pohl W (eds) (1989) Technical Recommendations and Guidelines for Bronchoalveolar Lavage (BAL) Eur. Respir. J. 2: 561

    Google Scholar 

  4. American Thoracic Society (1990) Clinical Role of Bronchoalveolar Lavage in Adults with Pulmonary Disease. Official ATS- statement. Am. Rev. Respir. Dis. 142: 481

    Google Scholar 

  5. Pirozynski M, Silwinski P, Polubiez M, Zielinski J and Radwan L (1988) Eur. Respir. J. 1 (Suppl. 2): 312

    Google Scholar 

  6. Klech H, Haslam, P, Turner-Warwick M and 62 other contributors (1986) Sarcoidosis 3: 113

    Google Scholar 

  7. Garcia JGN, Wolven RG, Garcia PL and Keogh BA (1986) Am. Rev. Respir. Dis. 133: 444

    PubMed  CAS  Google Scholar 

  8. Peterson MW, Nugent KM, Jolies H, Monick M and Hunninghake W (1988) Am. Rev. Respir. Dis. 137: 79

    Article  PubMed  CAS  Google Scholar 

  9. Pingleton AK, Harrison GF, Stechschulte DJ, Wesselius I.J, Kerby GR and Ruth WE (1983) Am. Rev. Respir. Dis. 128: 1035

    PubMed  CAS  Google Scholar 

  10. Burns DM, Shure D, Francoz R, Kalafer M, Harrell J, Witztum K and Moser KM (1983) Am. Rev. Respir. Dis. 127: 695

    PubMed  CAS  Google Scholar 

  11. Reynolds HY, Fulmer JD, Kazmierowsky JA, Roberts WC, Frank MM and Crystal RG (1977) J. Clin. Invest. 59: 165

    Article  PubMed  CAS  Google Scholar 

  12. Venet A, Clavel F, Israel-Biet D, Rouzioux C, Dennewald G, Stem MV, Vittecoq D, Regnier B, Cayrol E and Chretien J (1985) Bull Eur. Physiopathol. Respir. 21: 535

    PubMed  CAS  Google Scholar 

  13. Hunninghake, GW, Gadek JE, Kawanami O, Ferraris VJ and Crystal RG (1979) Am. J. Pathol. 97: 149

    PubMed  CAS  Google Scholar 

  14. Daniele RP, Elias JA, Epstein PE and Rossman MD (1985) Ann. Intern. Med. 102: 93

    PubMed  CAS  Google Scholar 

  15. Davis, GS, Giancola MS, Costanza MC and Low RB (1982) Am. Rev. Respir. Dis. 126: 611

    PubMed  CAS  Google Scholar 

  16. Lam S, Leriche JC, Kijek K and Phillips E (1985) Chest 88: 856

    Article  PubMed  CAS  Google Scholar 

  17. Dohn MN and Baughman RP (1985) Am. Rev. Respir. Dis. 132: 390

    PubMed  CAS  Google Scholar 

  18. Martin TR, Raghu G, Maunder RJ and Springmeyer SC (1985) Am. Rev. Respir. Dis. 132: 254

    PubMed  CAS  Google Scholar 

  19. Ettensohn DB, Jankowski MS, Duncan PG and Lalor PA (1988) Chest 94: 275

    Article  PubMed  CAS  Google Scholar 

  20. Dhillon DP, Haslam PL, Townsend PJ, Primett Z, Collins J-V and Turner-Warwick M (1986) Eur J Respir Dis 68: 342

    PubMed  CAS  Google Scholar 

  21. Reynolds HI and Newhall HH (1974) J. Lab. Clin. Med. 84: 559

    PubMed  CAS  Google Scholar 

  22. Davis WG, Rennard SI, Bittermann P and Crystal RG (1983) N. Engl. J. Med. 309: 878

    Article  PubMed  CAS  Google Scholar 

  23. Costabel, U (1994) Atlas der bronchoalveolären Lavage, Thieme Verlag Stuttgart-New York

    Google Scholar 

  24. Costabel U (1988) Prax. Klin. Pneumol. 42: 119

    Google Scholar 

  25. Haslam P, Turton C, Heard B et al. (1980) Thorax 35: 9

    Article  PubMed  CAS  Google Scholar 

  26. Thompson, A and Ghafouri, M (1988) Processing and Analysis of Broncholaveolar Lavage Specimens. In: Bronchoalveolar lavage, J Linder and S Rennard (eds), p. 17, ASCP Press Chicago

    Google Scholar 

  27. Grocott RC (1955) Am. J. Clin. Pathol. 25: 975

    PubMed  CAS  Google Scholar 

  28. Brinn NT (1983) I. Microtechnol. 6: 125

    CAS  Google Scholar 

  29. Unger ER, Budgeon LE, Myerson D et al. (1986) Am. J. Surg. Pathol. 10: 1

    Article  PubMed  CAS  Google Scholar 

  30. Brigati DJ, Myerson D, Leary JJ et al. (1983) Virology 126: 32

    Article  PubMed  CAS  Google Scholar 

  31. Myerson D, Hackman RC and Meyers JD (1984) J. Infect. Dis. 150: 272

    Article  PubMed  CAS  Google Scholar 

  32. Myerson D, Hackman RC, Nelson JA et al. (1984) Hum. Pathol. 15: 430

    Article  PubMed  CAS  Google Scholar 

  33. Hilborne L, Neiberg R, Cheng L et al. (1986) Lab. Invest. 26A

    Google Scholar 

  34. Parks DR and Herzenberg LA (1984) Fluorescence Activated Cell Sorting: Theory, Experimental Optimization and Application in Lymphoid Cell Biology. In: Methods in Enzymology,Kaplan NO and Colowick SP (eds) Academic Press New York

    Google Scholar 

  35. Pacheco Y, Cordier G, Perrin-Fayolle M and Revillard JP (1983) Am. J. Med. 73: 82

    Article  Google Scholar 

  36. Mornex JF, Cordier G, Pages J and Revillard JP (1983) Monogr. Allergy 18: 178

    PubMed  CAS  Google Scholar 

  37. Momex JF, Cordier G, Pages J, Vergnon JM, Lefebvre R, Brune J and Revillard JP (1984) J. Allergy Clin. Immunol. 74: 719

    Article  Google Scholar 

  38. Steward SJ, Fujiinoto J and Levy R (1986) J. Immunol. 136: 3773

    Google Scholar 

  39. Beuttner EH, Nisengard RJ and Albini B (1983) Ann. NYAcad. Sci. 420

    Google Scholar 

  40. Pizzolo G and Chilosi M (1984) Am. J. Clin. Pathol. 82: 44

    PubMed  CAS  Google Scholar 

  41. Costello JF, Moriarity DC, Branthwaite MA et al. (1975) Thorax 30: 121

    Article  PubMed  CAS  Google Scholar 

  42. Martin RJ, Coalson JJ, Rogers RM et al. (1980) Am. Rev. Respir. Dis. 121: 819

    PubMed  CAS  Google Scholar 

  43. Basset F, Soler P, Jaurand MC et al. (1977) Thorax 32: 303

    Article  PubMed  CAS  Google Scholar 

  44. Saltini C, Hance AJ, Ferrans VJ et al. (1984) Am. Rev. Respir. Dis. 130: 650

    PubMed  CAS  Google Scholar 

  45. Thompson A, Ghafouri M, Linder J et al. (1986) Am. Rev. Respir. Dis. 133: A82

    Google Scholar 

  46. Linder J, Vaughan WP, Armitage JO et al. (1987) Am. J. Clin. Pathol. 88: 421

    PubMed  CAS  Google Scholar 

  47. Johnston WW, Frable WJ (eds) (1979) Diagnostic Respiratory Cytopathology. Masson Publishing New York

    Google Scholar 

  48. Low RB, Davis GS and Giancola MS (1978) Am. Rev. Respir. Dis. 118: 863

    PubMed  CAS  Google Scholar 

  49. Rennard SI, Basset G, Lecossier D et al. (1986) J. Appl. Physiol. 60: 532

    PubMed  CAS  Google Scholar 

  50. Baughman RP, Bosken CH, Loudon RG, Hurtubise P and Wesseler T (1983) Am. Rev. Respir. Dis. 128: 266

    PubMed  CAS  Google Scholar 

  51. Gehr P, Bachofen M and Weibel ER (1978) Respir. Physiol. 32: 121

    Article  PubMed  CAS  Google Scholar 

  52. von Wichert P, Joseph K, Müller B and Franck WM (1993) Am. Rev. Respir. Dis. 147: 148

    Article  Google Scholar 

  53. Kleinholz EJ and Fussel J (1973) Am. Rev. Respir. Dis. 108: 1014

    PubMed  CAS  Google Scholar 

  54. Dubrawsky C, Awe RJ and Jenkins DE (1975) Chest 67: 137

    Article  PubMed  CAS  Google Scholar 

  55. Matsushima Y, Jones L, King E, Moysa G and Alton JD (1984) Chest 86: 184

    Article  PubMed  CAS  Google Scholar 

  56. Shrader DL and Lakshiminarayan S (1978) Chest 73: 821

    Article  PubMed  CAS  Google Scholar 

  57. Brach BB, Escano GE, Harrell JH and Moser KM (1976) Chest 69: 335

    Article  PubMed  CAS  Google Scholar 

  58. Lindholm CE, Oilman B, Snyder JV, Miller EG and Grenvik A (1978) Chest 74: 362

    Article  PubMed  CAS  Google Scholar 

  59. Pereira W, Kovnat DM, Anees Kahn M, Iacovino JR, Spivack ML and Snider GL (1975) Am. Rev. Respir. Dis. 112: 59

    PubMed  CAS  Google Scholar 

  60. Petro W, Linder O and Kaspar P (1989) Atemw. Lungenkrkh. 15: 614

    Google Scholar 

  61. Pirozinsky M, Zaleska J, Radwan L and Zych D (1991) Eur. Respir. Rev. 1 (Suppl): 17s

    Google Scholar 

  62. Cole P, Turton C, Lanyon H and Collins J (1980) Br. J. Dis. Chest. 74: 273

    Article  PubMed  CAS  Google Scholar 

  63. Strumpf U, Feld MK, Cornelius MJ, Keogh BA and Crystal RG (1981) Chest 80: 268

    Article  PubMed  CAS  Google Scholar 

  64. Gurney JW, Harrison WC, Sears K, Robbins RA, Dobvy CA and Rennard SI (1987) Radiology 163: 71

    PubMed  CAS  Google Scholar 

  65. Standiford TJ, Kunkel SL and Strieter RM (1991) Chest 99: 1529

    Article  PubMed  CAS  Google Scholar 

  66. Rankin JA, Synder PE, Schacter EN and Matthay RA (1984) Chest 85: 723

    Article  PubMed  CAS  Google Scholar 

  67. Tilles TS, Goldenheim PD, Ginns LC and Hales CA (1986) Chest 89: 244

    Article  PubMed  CAS  Google Scholar 

  68. Summary and Recommendations of a Workshop on the Investigative Use of Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Asthmatics (1985) Am. Rev. Respir. Dis. 132: 180

    Google Scholar 

  69. Henderson RF, Mauderly JL, Pickrell JA, Hahn FF, Muhle H and Rebar AH (1987) Exp. Lung Res. 13: 329

    Article  PubMed  CAS  Google Scholar 

  70. Mauderly J (1977) Lab. Anim. Sci. 27: 255

    PubMed  CAS  Google Scholar 

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Authors
  1. U. Wagner
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  2. P. von Wichert
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Editors and Affiliations

  1. Department of Pulmonary Pharmacology, Forschungszentrum Borstel, Parkallee 22, D-23845, Borstel, Germany

    Stefan Uhlig

  2. Department of Physiology College of Medicine, University of Southern Alabama, Mobile, AL, 36688, USA

    Aubrey E. Taylor

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© 1998 Springer Basel AG

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Wagner, U., von Wichert, P. (1998). Bronchoalveolar lavage. In: Uhlig, S., Taylor, A.E. (eds) Methods in Pulmonary Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8855-4_13

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  • DOI: https://doi.org/10.1007/978-3-0348-8855-4_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9803-4

  • Online ISBN: 978-3-0348-8855-4

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