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Biology of glial cell-line derived neurotrophic factor

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TGF-β and Related Cytokines in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Neurotrophic factors are cytokines that promote the differentiation, development, growth, maintenance and regeneration of neurons. In 1993, glial cell line-derived-neurotrophic factor (GDNF) was identified as the first member of a new family of cytokines in the transforming growth factor β (TGF-β) superfamily [1]. Over the past five years, three additional members of the GDNF family have been isolated, cloned and sequenced: neuturin [2], persephin [3] and artemin [4]. The present review will concentrate on GDNF, the most extensively studied of the four proteins. The known properties of the other three trophic factors and their comparison to GDNF will be discussed at the end of the chapter.

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Authors and Affiliations

  1. Department of Anatomy and Neurobiology, University of Kentucky Medical Center, 800 Rose Street, MN 224, Lexington, KY, 40536-0298, USA

    Navin Maswood & Don M. Gash

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Editors and Affiliations

  1. Centre for Immunology, St. Vincent’s Hospital & University of NSW, Victoria St., Sydney, NSW, 2010, Australia

    Samuel N. Breit

  2. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research National Institutes of Health, 30 Convent Drive, Bethesda, MD, 20878-4352, USA

    Sharon M. Wahl

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Maswood, N., Gash, D.M. (2001). Biology of glial cell-line derived neurotrophic factor. In: Breit, S.N., Wahl, S.M. (eds) TGF-β and Related Cytokines in Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8354-2_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8354-2_7

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