Abstract
The concept of osteoinductive or bone morphogenetic proteins (BMPs) was first introduced by Urist nearly 40 years ago [1], and by the late 1980’s the human cDNA for OP-1 (BMP-7) was cloned [2]. Utilizing recombinant technology, human OP-1 (rhOP-1) was produced and this molecule has demonstrated its capacity to induce bone formation [3, 4]. Subsequently, extensive preclinical and clinical research has confirmed the efficacy as well as safety of OP-1 in the process of bone repair and regeneration [5–8]. This paper will focus on clinical experience with OP-1 in the treatment of nonunions of the appendicular skeleton.
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References
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© 2002 Springer Basel AG
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Giltaij, L.R., Shimmin, A., Friedlaender, G.E. (2002). Osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones: clinical experience. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8121-0_10
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DOI: https://doi.org/10.1007/978-3-0348-8121-0_10
Publisher Name: Birkhäuser, Basel
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