Summary
Heparin, aspirin and the selective 5-HT2 antagonists ketanserin and pelanserin partially prevented the platelet-fall, rise en right ventricular pressure and systemic hypotension induced by the intravenous administration of an autologous clot or a suspension of collagen fibrils in rabbits. Whereas platelet-depletion nearly fully prevented the haemodynamic effects of the experimental thromboembolism. Intravenous 5-HT resembled the effects of pulmonary embolism and was only partially antagonized by the 5-HT2 receptor antagonists. These results suggest an additive role for platelet-derived vasoactive factors and thrombin in these experimental models and point out a role for 5-HT receptors eliciting reflex responses in the lung during the embolization.
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© 1991 Birkhäuser Verlag Basel/Switzerland
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Amezcua, J.L., Hong, E., Bobadilla, R.A. (1991). Effects of Selective 5-HT2 Receptor Antagonists on some Haemodynamic Changes Produced by Experimental Pulmonary Embolism in Rabbits. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_41
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DOI: https://doi.org/10.1007/978-3-0348-7259-1_41
Publisher Name: Birkhäuser Basel
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