Summary
Presynaptic inhibition of primary mechanoafferents in the crayfish abdomen, elicited during giant axon-mediated escape, protects primary afferent synapses from depression which would result from reafference during the tailflip. As in vertebrates, this inhibition is associated with primary afferent depolarization (PAD) ostensibly produced by a GABA-mediated increase in chloride conductance. We have physiologically and morphologically characterized the inhibitory interneurons (PADIs) directly responsible for producing PAD and presynaptic inhibition, identified elements of the pathways excited by the giant escape command cells which recruit the PADIs, and are currently studying the ultrastructure of synapses between the PADIs and afferent terminals.
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Kirk, M.D., Govind, C.K. (1990). Presynaptic Inhibition of Primary Afferent Synapses in the Crayfish. In: Wiese, K., Krenz, WD., Tautz, J., Reichert, H., Mulloney, B. (eds) Frontiers in Crustacean Neurobiology. Advances in Life Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5689-8_15
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DOI: https://doi.org/10.1007/978-3-0348-5689-8_15
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