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Brown Adipose Tissue: The Dominant Site of Nonshivering Thermogenesis in the Rat

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Effectors of Thermogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 32))

Abstract

Measurements with tracer microspheres of changes in tissue blood flow associated with noradrenaline (NA)-induced calorigenesis in warm-acclimated and in cold-acclimated (CA) rats revealed very large increases in flow to brown adipose tissue (BAT). The data on flow together with measurements of the arteriovenous difference in blood O2 across interscapular BAT indicate that BAT accounts for at least 60% of the NA-induced nonshivering thermogenesis (NST) of CA rats. Skeletal muscle was found to be only minimally, if at all, involved in this NST.

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Abbreviations

BAT:

brown adipose tissue

IBAT:

interscapular BAT

NST:

nonshivering thermogenesis

CA:

cold acclimated

WA:

warm-acclimated

NA:

noradrenaline

FD:

fractional distribution

CO:

cardiac output

(A-V)O2 :

arteriovenous difference in blood oxygen content

References

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Author information

Authors and Affiliations

  1. Division of Biological Sciences, National Research Council of Canada, Ottawa, K1A OR6, Canada

    David O. Foster & M. Lorraine Frydman

Authors
  1. David O. Foster
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  2. M. Lorraine Frydman
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Editor information

Editors and Affiliations

  1. Department of Physiology, Medical School, Geneva, Switzerland

    L. Girardier  & J. Seydoux  & 

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© 1978 Springer Basel AG

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Foster, D.O., Frydman, M.L. (1978). Brown Adipose Tissue: The Dominant Site of Nonshivering Thermogenesis in the Rat. In: Girardier, L., Seydoux, J. (eds) Effectors of Thermogenesis. Experientia Supplementum, vol 32. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5559-4_16

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  • DOI: https://doi.org/10.1007/978-3-0348-5559-4_16

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5561-7

  • Online ISBN: 978-3-0348-5559-4

  • eBook Packages: Springer Book Archive

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