Abstract
Fluciclovine is used to assess amino acid transport in tumours and is particularly useful in prostate cancer.
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Chemical name and alternative names | Chemical structure |
|---|---|
Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid; FACBC; Axumin™ (Blue Earth Diagnostics) |
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Route of Synthesis
Nucleophilic attack of 18F-fluoride on triflate precursor, followed by deprotection with HCl and purification using solid phase extraction cartridges.
Normal Biodistribution and Excretion
Highest initial uptake in liver, bone marrow, and lung. Very little urinary or hepatobiliary excretion (~3% in urine over 4 h) (Sörensen et al. 2013).
Activity Administered
370 MBq.
Radiation Dosimetry
Effective dose equivalent (mSv/MBq): 0.022 (8 mSv/370 MBq).
Organ doses (mGy/MBq): pancreas, 0.10; cardiac wall, 0.05; uterine wall, 0.04 (McParland et al. 2013).
Patient Preparation
Patients should avoid significant exercise for 1 day before imaging. Patients should not eat or drink for 4 h before imaging.
Further Reading
Marcus C, Butler P, Bagrodia A, Cole S, et al. Fluorine-18-labeled fluciclovine PET/CT in primary and biochemical recurrent prostate cancer management. AJR Am J Roentgenol. 2020;215:267–76.
McParland BJ, Wall A, Johansson S, et al. The clinical safety, biodistribution and internal radiation dosimetry of [18F]fluciclovine in healthy adult volunteers. Eur J Nucl Med Mol Imaging. 2013;40:1256–64.
Nanni C, Zanoni L, Bach-Gansmo T, et al. [18F]Fluciclovine PET/CT: joint EANM and SNMMI procedure guideline for prostate cancer imaging–version 1.0. Eur J Nucl Med Mol Imaging. 2020;47:579–591.
Nanni C, Zanoni L, Pultrone C, et al. 18F-FACBC (anti1-amino-3-18F-fluorocyclobutane-1-carboxylic acid) versus 11C-choline PET/CT in prostate cancer relapse: results of a prospective trial. Eur J Nucl Med Mol Imaging. 2016;43:1601–1610.
Sörensen J, Owenius R, Lax M, et al. Regional distribution and kinetics of [18F]fluciclovine (anti-[18F]FACBC), a tracer of amino acid transport, in subjects with primary prostate cancer. Eur J Nucl Med Mol Imaging. 2013;40:394–402.
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Ballinger, J.R. (2022). 18F-Fluciclovine (FACBC). In: PET Radiopharmaceuticals. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-031-10271-4_13
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DOI: https://doi.org/10.1007/978-3-031-10271-4_13
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