Abstract
Fluciclatide is used for imaging angiogenesis.
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Chemical name and alternative names | Chemical structure |
|---|---|
AH111585 |
|
Route of Synthesis
Coupling of 4-18F-fluorobenzaldehyde with aminooxy-functionalised precursor to form oxime.
Normal Biodistribution and Excretion
Initial high uptake in liver, spleen, and heart wall followed by clearance. Excretion is 37% via kidneys and 20% via liver. Biological half-life in whole blood is 0.25 h (McParland et al. 2008).
Activity Administered
370 MBq.
Radiation Dosimetry
Effective dose equivalent (mSv/MBq): 0.026 (10 mSv/370 MBq).
Organ doses (mGy/MBq): urinary bladder wall, 0.12; kidneys, 0.10; cardiac wall 0.06 (McParland et al. 2008).
Patient Preparation
Patient preparation is not standardised yet.
Further Reading
McParland BJ, Miller MP, Spinks TJ, et al. The biodistribution and radiation dosimetry of the Arg-Gly-asp peptide 18F-AH111585 in healthy volunteers. J Nucl Med. 2008;49:1664–7.
Mena E, Owenius R, Turkbey B, et al. [18F]Fluciclatide in the in vivo evaluation of human melanoma and renal tumors expressing αvβ3 and αvβ5 integrins. Eur J Nucl Med Mol Imaging. 2014;41:1879–1888.
Sharma R, Kallur KG, Ryu JS, et al. Multicenter reproducibility of 18F-fluciclatide PET imaging in subjects with solid tumors. J Nucl Med. 2015;56:1855–61.
Sharma R, Valls PO, Inglese M, et al. [18F]Fluciclatide PET as a biomarker of response to combination therapy of pazopanib and paclitaxel in platinum-resistant/refractory ovarian cancer. Eur J Nucl Med Mol Imaging. 2020;47:1239–1251.
Tomasi G, Kenny L, Mauri F, et al. Quantification of receptor-ligand binding with [18F]fluciclatide in metastatic breast cancer patients. Eur J Nucl Med Mol Imaging. 2011;38:2186–97.
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Ballinger, J.R. (2022). 18F-Fluciclatide. In: PET Radiopharmaceuticals. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-031-10271-4_11
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DOI: https://doi.org/10.1007/978-3-031-10271-4_11
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